尼可地尔对顽固性心绞痛患者心绞痛发作及心电图ST-T段的影响

Impact of Nicorandil on Angina Pectoris Attacks and ECG ST-T Segment in Patients with Intractable Angina Pectoris

目的探讨尼可地尔对顽固性心绞痛患者心绞痛发作及心电图ST-T段的影响。方法选取孝感市中心医院2012年4月—2015年4月收治的顽固性心绞痛患者80例,根据治疗方法不同分为研究组和对照组,各40例。两组患者均给予基础治疗,研究组患者给予尼可地尔治疗,对照组患者给予安慰剂治疗,两组患者均以4周为1个疗程。比较两组患者临床疗效和心电图ST-T段改善情况,治疗前后心绞痛发作频率和持续时间,治疗期间观察两组患者不良反应发生情况。结果两组患者临床疗效和心电图ST-T段改善情况比较,差异无统计学意义(u值分别为1.883和0.727,P值分别为0.060和0.467)。治疗前两组患者心绞痛发作频率和持续时间比较,差异无统计学意义(P>0.05);治疗后研究组患者心绞痛发作频率低于对照组,持续时间短于对照组(P<0.05)。治疗期间研究组不良反应发生率为30.0%,对照组为25.0%,差异无统计学意义(P>0.05)。结论尼可地尔能有效减少顽固性心绞痛患者心绞痛发作频率,缩短心绞痛持续时间,且安全性较高,但其改善心电图ST-T段效果不明显。

Objective To investigate the impact of nicorandil on angina pectoris attacks and ECG ST- T segment in patients with intractable angina pectoris. Methods A total of 80 patients with intractable angina pectoris were selected in the Central Hospital of Xiaogan from April 2012 to April 2015,and they were divided into control group and study group according to different therapeutic methods,each of 40 cases. Based on basic treatment,patients of control group were given placebo,while patients of study group were given nicorandil,both groups treated for 4 weeks as a course. Clinical effect,ECG ST- T segment improvement effect,attack frequency and duration of angina pectoris before and after treatment were compared between the two groups,and incidence of adverse reactions during treatment was observed. Results No statistically significant differences of clinical effect or ECG ST- T segment improvement effect was found between the two groups（ u = 1. 883,0. 727; P = 0. 060,0. 467）. No statistically significant differences of attack frequency or duration of angina pectoris was found between the two groups before treatment（ P〉0. 05）; after treatment,attack frequency of study group was statistically significantly lower than that of control group,and duration of angina pectoris of study group was statistically significantly shorter than that of control group（ P〈0. 05）. The incidence of adverse reactions of control group was 25. 0%,that of study group was 30. 0%,the difference was not statistically significantly different（ P〉0. 05）. Conclusion Nicorandil can effectively reduce the attack frequency of angina pectoris,shorten the duration of angina pectoris,and is safe,but its ECG ST- T segment improvement effect is not obviously effective.