冠心病患者Hcy、IL-6、BNP水平与冠状动脉病变关系的临床研究

Clinical research of the relationship between coronary artery disease and level of Hcy,IL-6 and BNP in patients with coronary heart disease

目的 探讨血清同型半胱氨酸（Hcy）、白细胞介素-6（IL-6）、B型利钠肽（BNP）水平与冠心病（CHD）病变的关系。方法 选取本院2012年1月~2014年10月确诊的180例CHD患者作为冠心病组,另选取96例非CHD者作为对照组。按临床分型将冠心病组分为急性心肌梗死组（AMI）68例、不稳定型心绞痛组（UAP）72例和稳定型心绞痛组（SAP）40例,测定3组的血清Hcy、IL-6、BNP水平。结果 冠心病组的Hcy、IL-6和BNP水平显著高于对照组,差异有统计学意义（P〈0.05）。AMI组的Hcy、IL-6和BNP水平显著高于UAP组和SAP组,差异有统计学意义（P〈0.05）。UAP组的Hcy、IL-6和BNP水平显著高于SAP组,差异有统计学意义（P〈0.05）。结论 Hcy、IL-6、BNP水平在CHD患者中明显升高,Hcy、IL-6、BNP与不同类型CHD病变程度成正相关。

Objective To explore the relationship between coronary heart disease （CHD） and the level of Hcy,IL-6 and BNP. Methods 180 patients with CHD from January 2012 to October 2014 in our hospital were selected as the CHD group,and 96 eases without CHD were selected as the control group.The CHD group was divided into acute myocardial infarction （AMI） group （n=68）,unstahle angina peetoris （UAP） group （n=72） and stable angina pectoris （SAP） group （n= 40）,and the level of Hcy,IL-6 and BNP among three groups was determined respectively. Results The level of Hcy,IL- 6 and BNP in the CHD group was higher than that in the control group,with significant difference （P〈0.05）.The level of Hcy,IL-6 and BNP in the AMI group was higher than that in the UAP group and the SAP group,with significant differ- ence （P〈0.05）.The level of Hcy,IL-6 and BNP in the UAP group was higher than that in the SAP group,with significant difference （P〈0.05）. Conclusion The level of Hcy,IL-6 and BNP are significant increased in CHD patients,and there is positive correlation with CHD degree.