山莨菪碱在小儿支气管肺炎治疗中的辅助作用研究

Auxiliary role study of anisodamine in children with bronchial pneumonia

目的 探讨山莨菪碱在小儿支气管肺炎治疗中的辅助作用。方法 选择2013年1月~2014年12月本院儿科收治的小儿支气管肺炎患儿78例,按随机数字表法分为研究组和对照组,各39例,对照组患者给予镇咳、平喘、抗感染等常规治疗,研究组在对照组治疗的基础上加用小剂量山莨菪碱治疗,0.2~0.3 mg/（kg·d）,连续治疗5~7 d,观察两组患者咳嗽、喘憋、肺部啰音消失时间及住院时间,通过症状体征改善情况评价两组治疗效果。结果研究组治疗总有效率为94.9%,明显高于对照组的79.5%,组间比较差异有统计学意义（χ2=4.761,P〈0.05）。研究组咳嗽、喘憋、肺部啰音消失时间,胸片恢复时间及住院时间明显短于对照组[（4.25±1.37）、（1.69±0.58）、（5.26±1.20）、（4.85±1.13）、（7.37±2.45）d vs（7.50±2.15）、（2.96±0.97）、（7.02±0.37）、（6.84±1.53）、（10.43±2.26）d],组间比较差异有统计学意义（t=4.206、3.914、3.983、4.579、5.235,P〈0.05）。结论 小剂量山莨菪碱辅助治疗小儿支气管肺炎可促进肺部症状体征的消失,缩短病程,值得应用。

Objective To explore the auxiliary role of anisodamine in children with bronchial pneumonia. Methods 78 children with bronchial pneumonia from January 2013 to December 2014 of our hospital were selected.Patients were di- vided into study group and control group by random number table,and each group was 39 cases.Patients in control group were given routine therapy liked relieving cough,relieving asthma and anti-infection.Patients in study group were given further low dosage of anisodamine [0.2 to 0.3 mg/（kg.d）]for 5 to 7 d continuous treatment on the basis of control group.The disappearance time of cough and pulmonary tales and hospital stays were observed between two groups.The therapy effect between two groups was valued by the situation of symptoms and signs improved. Results The total effec- tive in study group was 94.4%,which significantly higher than that was 79.5% in control group,and the difference was statistical significance（χ2=4.761,P〈0.05）.The disappearance time of cough,dyspnea and pulmonary rales,chest radiograph recovery time and hospital stays were significantly shorter than control group [（4.25±1.37）,（1.69±0.58）,（5.26±1.20）, （4.85±1.13）,（7.37±2.45）d vs （7.50±2.15）,（2.96±0.97）,（7.02±0.37）,（6.84±1.53）,（10.43±2.26）d],and the difference was sta- tistical significance（t=4.206,3.914,3.983,4.579,5.235,P〈0.05）. Conclusion Low dosage of anisodamine adjuvant therapy children with bronchial pneumonia can promote pulmonary symptoms and signs disappeared,shorten the course.h is worth to application.