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药物中间体4-甲磺酰基苯乙酸合成研究进展

Research Progress on Synthesis of Drug Intermediate 4-(Methylsulfonyl)phenylacetic Acid
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摘要 指出了4-甲磺酰基苯乙酸是一种非常有用的医药中间体。归纳了4种合成4-甲磺酰基苯乙酸方法,从中总结出了以茴香硫醚为原料依次通过Friedel-Crafts酰基化反应和Willgerodt-Kindler重排反应制备4-甲磺酰基苯乙酸,该合成路线具有操作简单,成本低,环境友好,比较适合于工业化。 The 4-（methylsulfonyl）phenylacetic acid is a very useful drug intermediate. This article summarizes four methods for preparation of 4-（methylsulfonyl）phenylacetic acid. Taking the thioanisole as raw material and then through Friedel-Crafts acylation reaction and Willgerodt--Kindler rearrangement reaction, 4 - （methylsulfonyl）phenylacetie acid is prepared. The method has many advantages,such as simple operations, low production cost, environmental friendly and suitable for industrialization.
作者 王坤 唐婧 王芬
机构地区 四川文理学院化学化工学院 四川文理学院四川革命老区发展研究中心
出处 《绿色科技》 2015年第11期250-251,共2页 Journal of Green Science and Technology
基金 四川省教育厅自筹科研项目(编号:12ZB315) 四川文理学院面上项目资助(编号:2013Z007Y) 大学生科研项目(编号:X2014Z010)资助
关键词 茴香硫醚 4-甲磺酰基苯乙酸 合成 thioanisole 4 - （methylsulfonyl） phenylacetic acid synthesis
分类号 TQ032.42 [化学工程]
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参考文献11

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