贝那普利联合低分子肝素对大鼠肾纤维化的作用研究被引量：1

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摘要肾间质纤维化是指在各种致病因子作用下,间质细胞及细胞基质蛋白合成增加,降解受抑制造成细胞外基质（ECM）的大量堆积导致的[1]。低分子肝素（LMWH）具有抑制肾小球系膜细胞和基质增生的作用及抗肾间质纤维化作用[1]。本文通过观察联用贝那普利和LMWH与单用贝那普利对转化生长因子-β1（TGF-β1）、基质金属蛋白酶-2（MMP-2）的表达和对肾组织结构的影响,以探讨药物对肾间质纤维化的作用效果，并为临床治疗提供更多的理论依据。

作者卢涛朱春玲

机构地区海口市人民医院肾内科贵阳医学院附属医院肾内科

出处《贵州医药》 CAS 2015年第10期893-894,共2页 Guizhou Medical Journal

关键词贝那普利低分子肝素肾间质纤维化

分类号 R972 [医药卫生—药品]

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