前列舒通联合左氧氟沙星治疗慢性细菌性前列腺炎的临床疗效及安全性评价

Clinical efficacy and safety of Qianlieshutong capsule combined with levofloxacin in treatment of chronic bacteritic prostatitis

目的评价前列舒通联合左氧氟沙星治疗慢性细菌性前列腺炎的临床疗效和安全性。方法将135例慢性细菌性前列腺炎患者随机分为试验组71例和对照组64例。试验组予以口服前列舒通,每次0.4 g,每日3次+左氧氟沙星,每次0.1 g,每日2次;对照组予以左氧氟沙星,每次0.1 g,每日2次。2组患者疗程均为2周。比较2组患者的临床疗效、细菌学疗效和不良反应发生率。结果试验组的有效率为60.56%显著优于对照组51.56%(P<0.05)。试验组的细菌清除率为100.00%显著优于对照组72.22%(P<0.05)。试验组和对照组的不良反应发生率分别为4.23%和3.13%,差异无统计学意义(P>0.05)。结论前列舒通联合左氧氟沙星治疗前列腺炎的临床疗效确切,且不增加不良反应的发生率。

Objective To evaluate the clinical efficacy and safety of the combination of Qianlieshutong and levofloxacin in the treatment of pa- tients with chronic bacterial prostatitis. Methods One hundred thirty- five patients with chronic bacterial prostatitis were randomly divided into treatment group （ n = 71 ） and control group （ n = 64）. Patients in treat- ment group were treated with qianlieshutong 0. 4 g, po, 3 times a day and levofloxacin 0. 1 g, twice a day. Patients in control group were trea- ted with levofloxacin 0. 1 g, twice a day. The course of treatment was 2 weeks in two groups. The clinical efficacy, bacteriological efficacy and incidence of adverse drug reactions between the two groups were com- pared. Results The effective rate of treatment group （60. 56% ） was significantly higher than that of control group （51.56%, P 〈 0. 05 ）. The bacterial clear rate of treatment group （100. 00% ） was significantly higher than that of control group （72.22% , P 〈0. 05）. The incidences of adverse reactions were 4.23% and 3.13% in the treatment group and control group respectively without statistical difference （P 〉 0. 05 ）. The clinical efficacy of Qianlieshutong combine with levofloxacin in the treatment of prostatitis is exact, and without increasing incidence of adverse drug reactions.