急性缺氧和高浓度磷化氢对小白鼠行为及器官的影响

Influence of acute hypoxia and high concentrations of phosphine on the behavior and organs of rat

为研究急性缺氧和高浓度磷化氢对小白鼠行为及器官的影响,随机取小白鼠,不分雌雄,置于3.0%、4.4%、6.4%、20.9%(对照)4个氧气浓度和0(对照)、200、600 ml/L 3个磷化氢浓度气体环境中,观察记录小白鼠的行为,同时解剖分析组织器官的变化。实验表明,急性缺氧和高浓度磷化氢条件下,小白鼠的行为表现不同,主要表现为:急性缺氧条件下,小白鼠腹部抖动加速,呼吸急促;高浓度磷化氢条件下,小白鼠出现间歇性兴奋,具体表现为不停蹦跳。小白鼠肺部器官变化明显,主要表现为周边肺小泡出现补偿性扩增、肺泡出血、纤维蛋白进入肺泡腔;心、肝、脾、肾等器官未出现明显的变化。

The influence of acute hypoxia and high concentrations of phosphine on the behavior and organs of rats was studied. Female or male rats were selected randomly to groups and were put into the atmosphere with the oxygen concentration of 3.0%, 4.4%, 6.4%, 20.9% （ control group） and phosphine concentration of 0 （ control group） , 200, 600 mL/L. During that time the behaviors of the rats were recorded and then the organs were dissected to analyse the change. The results showed that under the condition of acute hypoxia and high concentrations of phosphine, the behaviors of the rats were different： under the condition of acute hypoxia, the abdomen of rats dithered quickly and breathed rapidly;under the condition of high concentrations of phosphine, rats behaved intermittent excited as constantly jumping. The lung organ of rats changed significantly. The main performance was that the peripheral pulmonary vesicles appeared compensatory amplification, alveolar hemorrhaged and fibrin entered into the alveolar space. There was no obvious change in the heart, liver, spleen, kidney and other organs.