米非司酮联合米索前列醇终止妊娠的临床效果及安全性分析

Analysis on the clinical effect and safety of mifepristone combined with misoprostol in termination of pregnancy

目的探究中期妊娠产妇给予米非司酮联合米索前列醇终止妊娠的临床成效及安全性,寻找此类产妇终止妊娠最科学的医疗手段。方法选取2010年3月-2013年10月该院妇产科收治的自愿行人工引产的中期妊娠孕妇88例,随机分为研究组和对照组,每组各44例。研究组开展米非司酮联合米索前列醇引产,对照组开展利凡诺行羊膜腔内注射法引产。分析两组成功引产率、引产时间、引产出血量、引产残留物及不良反应发生率的差异。结果研究组引产成功率高于对照组,引产时间和不良反应发生率低于对照组,引产残留物少于对照组,差异均有统计学意义(P均<0.05);两组在引产出血量方面比较,差异无统计学意义(P>0.05)。结论中期妊娠妇女实施米非司酮联合米索前列醇引产能提高引产质量,缩短引产时间,安全性更佳,可取得较为满意的临床成效。

Objective To explore the clinical effect and safety of mifepristone combined with misoprostol in termination of intermediate pregnancy, find the most scientific medical treatment for these women. Methods Eighty-eight intermediate pregnant women undergoing artificial abortion voluntarily in Department of Gynecology and Obstetrics in the hospital from March 2010 to October 2013 were selected and randomly divided into study group and control group, 44 cases in each group. The cases in study group were treated by mifepristone combined with misoprostol for induced labor, while the Cases in control group were treated by intra-amniotic injection of rivanol for induced la- bor. The successful induced labor rates, induction time, bleeding volumes of induction, the residues of induced labor, and the incidence rates of adverse reactions in the two groups were analyzed. Results The successful rate of induced labor in study group was higher than that in control group, the induction time and the incidence rate of adverse reactions in study group were lower than those in control group, the residues of induced labor were less than those in control group, there were statistically significant differences （ P〈0. 05 ） . There was no statistically significant difference in bleeding volume of induced abortion between the two groups （ P〉0. 05） . Conclusion Induced abortion of intermediate pregnancy using mifepristone combined with misoprostol can improve the quality, shorten induction time, the safety is high, which can achieve satisfactory clinical effectiveness.