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VCAM-1、IFN-α和ES在稽留流产患者外周血中的表达及意义 被引量：3

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摘要 目的探讨稽留流产患者外周血中血管粘附分子-1(VCAM-1)、干扰素-α(IFN-α)、内皮抑素(ES)的表达水平及其临床意义。方法采用酶联免疫吸附测定法分别测定45例稽留流产患者(流产组)和45例正常早孕孕妇(对照组)外周血中VCAM-1、IFN-α及ES的表达水平。结果流产组患者外周血中VCAM-1、IFN-α及ES水平分别为(296.7±67.4)μg/l、(58.2±13.6)pg/ml及(61.3±19.8)ng/ml,对照组分别为(485.6±96.1)μg/l、(18.4±6.2)pg/ml及(22.4±6.8)ng/ml,两组比较差异有统计学意义(P<0.05)。结论稽留流产患者外周血中的VCAM-1低水平表达,IFN-α及ES高水平表达可能是其重要发病机制之一。
作者 刘亚莉 张庆华 闫金菊
机构地区 湖北省武汉市中心医院妇产科 十堰市妇女儿童医院妇产科
出处 《中国妇幼保健》 CAS 2015年第33期5820-5821,共2页 Maternal and Child Health Care of China
基金 湖北省十堰市科研立项项目〔2013076〕
关键词 稽留流产 外周血 血管粘附分子-1 干扰素-Α 内皮抑素
分类号 R714.21 [医药卫生—妇产科学]
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参考文献11

  • 1Diejomaoh MF, Alazemi M, Jirous J, et al. Theatiology and pattern of recurrent pregnancy loss ( J ~ . J Obstet Gynaecol, 2002, 22 (1) : 62-67.
  • 2Diejomaoh M, Jirous J, AI-Azemi M, et al. The relationship of recurrent spontaneous miscarriage with reproductive failure (J~ . Meal Princ Pract, 2003, 12 (2) : 107-111.
  • 3Koch AE, Hailoran MM, Haskell C J, et al. Angiogenesis me- diated by soluble forms of E-selectin and va.scular cell adhesion molecule-1 ~J3 .Nature, 1995, 376 (6540): 517-519.
  • 4Nakao S, Kuwano T, Ishibashi T, et al. Synergistic effect of TNF-c~ in soluble VCAM- 1 induced angiogenesis through a 4- integrins [J] .J Immunol, 2003, 170 (11): 5704-5711.
  • 5Zhou Y, Damsky CH, Fisher SJ. Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular ad- hesion phenotype. One cause of defective endovascular invasion in this syndrome [J] .J Clin Invest, 1997, 99 (9): 2152-2164.
  • 6李绮玲,梁润彩,高眉扬.血管细胞黏附子-1(VCAM-1)在重度子痫前期胎盘的异常表达及其意义[J].海南医学,2008,19(5):114-115. 被引量：1
  • 7王鲁,汤钊猷,孙惠川,钦伦秀,纪元,薛琼,吴志全,刘银坤,叶胜龙.抗肿瘤血管形成剂抑制肝癌生长及转移的实验研究[J].中华肝胆外科杂志,2002,8(12):723-727. 被引量：11
  • 8Adam L, Black PC, Kassouf W, et al. Adenoviral mediated interferon-a 2b gene therapy suppresses the proangiogenic effect of vascular endothelial growth factor insuperf icial blad- der cancer [J3 . J Urol, 2007, 177 (5) : 1900-1906.
  • 9O'Reilly MS, Boehm T, Shing Y, et al. Endostation: an endogenous inhibitor of angiogenesis and tumor growth ~ J 1. Cell, 1997, 88 (2): 277-285.
  • 10Kim YM, Yun J, Lee CK, et al. Inhibitory effect on tyrosi- nase and mechamism of action [ J 3 . J Biol Chem, 2002, 277 (18),: 16340-16344.

二级参考文献17

  • 1陈汉平,黄引萍,马庭元.妊高征胎盘的免疫病理性损伤及类型[J].中华妇产科杂志,1996,31(9):540-542. 被引量：23
  • 2Yoshiji H, Kuriyama S, Hichlin DJ, et al. KDR/Flk-1 is a major regulator of vascular endothelial growth factor-induced tumor development and angiogenesis in murine hepatocellular carcinoma cells. Hepatology, 1999,30:1179-1186.
  • 3Chow NH, Hsu PI, Lin XZ, et al. Expression of vascular endo thelial growth factor in normal and hepatocellular carcinoma: an immunohistochemical study. HumPathol,1997,28:698-703.
  • 4Gallo O, Masini E, Morbidelli L, et al. Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer. J Natl Cancer Inst, 1998,90: 587-596.
  • 5Chin K, Kurashima Y, Ogura T, et al. Induction of vascular endothelial growth factor by nitric oxide in human glioblastoma and hepatocellular carcinoma cells. Oncogene, 1997, 15:437-442.
  • 6Majewski S, Szmurlo A, Marcak M, et al. Inhibition of tumor cell-induced angiogenesis by retinoids, 1,25-dihydroxyvitamin D3 and their combinations. Cancer Lett, 1993,75: 35-39.
  • 7Sun FX, Tang ZY, Liu KD, et al. Establishment of a metastatic model of human hepatocellular carcinoma in nude mice via ortho topic implantation of histologically intact tissues. Int J Cancer,1996,66:239-243.
  • 8Ziche M, Morbidelli L, Masini E, et al. Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J Clin Invest, 1994, 94: 2036-2044.
  • 9Vermeulen PB, Gasparini G, Fox SB, et al. Quantification of angiogenesis in solid human tumors: an international consensus on the methoodolgy and criteria of evaluation. Eur J Cancer,1996,32A:2472-2484.
  • 10Holmgren L, O' Reilly MS, Folkman J. Dormancy of micrometastases-balance proliferation and apoptosis in the presence of an giogenesis suppression. Nat Med, 1995,1:149-153.

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中国妇幼保健
2015年 第33期

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