多囊卵巢综合征患者血清性激素结合球蛋白含量与血脂紊乱的相关性分析

Correlation analysis of sex hormone binding globulin content with dyslipidemia in women with polycystic ovary syndrome

目的探讨PCOS患者体内SHBG含量与血脂紊乱的相关性。方法选择在本院就诊的未经过药物治疗的PCOS患者219例,分别检测其血清SHBG含量及血脂相关指标,并对其进行统计分析。结果 SHBG低值组的BMI、TG、LDL-C及Apo B明显高于SHBG高值组,而HDL-C及Apo AI明显低于SHBG高值组(P<0.05)。血清SHBG水平与HDL-C及Apo AI呈正相关,而与BMI及TG呈负相关(P<0.05)。结论血清SHBG含量的降低,可能是PCOS患者发生血脂紊乱的危险因素之一。

Objective To discuss the relationship of sex hormone binding globulin（ SHBG） with dyslipidemia in women with polycystic ovary syndrome（ PCOS）. Methods 219 untreated women with PCOS were enrolled in this study. The levels of serum SHBG and lipid profiles were measured and the results were analyzed statistically. Results The BMI,triglyceride（ TG）,low- density lipoprotein（ LDL- C） and apolipoprotein- B（ Apo B） levels in the low SHBG group were significantly higher than that in the high SHBG group,but high- density lipoprotein（ HDL- C） and apolipoprotein- A（ Apo AI） levels were significantly lower in the higher SHBG group（ P〈 0. 05）. The SHBG level was positively correlated with the HDL- C and Apo AI levels,but inversely related to BMI and TG（ P〈 0. 05）. Conclusion Lower level of SHBG might be a risk factor for women with PCOS complicated with dyslipidemia.