脂多糖结合蛋白、血清淀粉样蛋白A和降钙素原在自发性腹膜炎患者中的应用

The application of lipopolysaccharide binding protein,serum amyloid A and procalcitonin in patient with spontaneous bacterial peritonitis

目的探讨脂多糖结合蛋白(LBP)、血清淀粉样蛋白A(SAA)和降钙素原(PCT)在自发性腹膜炎(SBP)患者中的表达水平及其应用价值。方法选取2012年1月-2014年6月肝硬化腹水患者125例,分为SBP组64例,非SBP组61例。采用酶联免疫吸附法(ELISA)检测LBP,采用免疫比浊法检测SAA,采用免疫化学发光法(ILMA)测定PCT。结果 LBP、SAA和PCT在SBP组表达水平显著高于非SBP组和对照组,差异有统计学意义(P<0.05);治疗有效患者治疗前的LBP、SAA和PCT表达水平显著高于治疗后恢复期,差异有统计学意义(P<0.05);LBP、SAA和PCT在死亡组表达水平显著高于存活组,差异有统计学意义(P<0.05)。结论 SBP患者血清LBP、SAA和PCT均有较高的表达,并与疾病严重程度及预后密切相关。

Objective To study the expression level and its application value of lipopolysaccharide binding protein（ LBP）,serum amyloid A（ SAA） and procalcitonin（ PCT） in patients with spontaneous peritonitis（ SBP）. Methods A total of 125 patients were selected from January 2012 to June 2014,including SBP group 64 cases and non SBP group 61 cases. LBP was tested by enzyme- linked- immunosorbent（ ELISA）,SAA was tested by immunoturbidimetry,PCT was tested with immune chemiluminescence（ ILMA）. Results The levels of LBP,SAA and PCT in SBP group had a significantly higher expression than that of non SBP group and the control group（ P〈 0. 05）. The levels of LBP,SAA and PCT in patients with SBP group who were treated effectively before treatment had a significantly higher expression than that of recovery stage after treatment（ P〈 0. 05）. The levels of LBP,SAA and PCT in death group were significantly higher expression than that of the survival group（ P〈 0. 05）. Conclusion The expression levels of LBP,SAA and PCT in patients with SBP are significantly higher,and the change of LBP,SAA and PCT are correlated with the condition and prognosis of this disease.