NT-proBNP及TNF-α、IL-1β在成人轻症病毒性心肌炎中的变化及意义

Changes and significance of NT-proBNP,TNF-α and IL-1β in patients with adult mild viral myocarditis

目的探讨血清NT-pro BNP水平与病毒性心肌炎炎症反应程度之间的关系。方法随机入选38例成人轻症病毒性心肌炎(VMC)患者和40例健康志愿者,抽取2组入选者静脉血,分别运用双抗体夹心ELISA法测定其血清TNF-α、IL-1β水平;电化学发光免疫分析法测定其血清NT-pro BNP水平,检测结果运用SPSS 16.0统计软件进行数据分析。结果成人轻症病毒性心肌炎患者其血清NT-pro BNP、TNF-α和IL-1β水平均明显高于健康对照者,差异有统计学意义(P<0.05),且血清NT-pro BNP水平升高与TNF-α及IL-1β水平升高呈正相关(r值分别为0.671、0.786,P<0.05)。结论 NT-pro BNP可独立于血流动力学改变等因素的影响而在病毒性心肌炎患者中表现为其血清学水平升高,可作为一个间接指标用于评估心肌炎症反应程度。

Objective To estimate the relationship between NT- pro BNP levels and the degree of inflammation in viral myocarditis. Methods 38 patients with adult mild viral myocarditis and 40 healthy volunteers were included in our study. Blood was collected from the two enrolled patients respectively. The serum tumor necrosis factor- α（ TNF- α） and interleukin- 1β（ IL-1β） levels were also detected by enzyme linked immunosorbent assay（ ELISA）. The NT- pro BNP levels of all selected objects were measured by electrochemical luminescence immunoassay. The data was analyzed by using SPSS 16. 0 statistical software.Results Compared with the healthy volunteers,the serum levels of NT- pro BNP,TNF- α and IL- 1β were higher in the adult mild viral myocarditis group,and the difference had statistical significance（ P〈 0. 05）,and the NT- pro BNP levels were positively correlated with TNF- α levels or IL- 1β levels（ r = 0. 671,0. 786,P〈 0. 05）. Conclusion The elevated serum levels of NT- pro BNP in patients with viral myocarditis can be determined for inflammation other than the hemodynamic status of the patients. These results suggest that NT- pro BNP can be used as an indirect index to evaluate the degree of myocardial inflammatory reaction.