两种驱虫药物驱除羊肝片吸虫的效力试验

Efficacy Trials of Expelling Fasciola Hepatica by Two Anthelmintic In Sheep

应用三氯苯咪唑片剂和氯氰碘柳胺钠注射液,选择6-8月龄自然感染肝片吸虫的绵羊80只进行驱虫试验。结果：（1）三氯苯咪唑片剂5、10、15 mg/kg体重剂量对肝片吸虫的虫卵转阴率、减少率和成虫的驱虫率均达100.0%,对肝片吸虫幼虫的驱虫率分别为93.9%、100.0%和100.0%;（2）氯氰碘柳胺钠注射液5、10、15 mg/kg体重剂量对肝片吸虫的虫卵转阴率分别为60.0%、80.0%和100.0%,减少率分别为89.2%、98.2%和100.0%,对成虫驱虫率均分别为97.9%、100.0%和100.0%,幼虫驱虫率分别为90.7%、94.3%和100.0%;（3）三氯苯咪唑片剂10 mg/kg体重剂量与同剂量对照药物三氯苯咪唑混悬剂的驱虫效果无差异;（4）三氯苯咪唑片剂和氯氰碘柳胺钠注射液3个剂量组试验羊未见异常反应。试验证明,三氯苯咪唑片剂5、10、15 mg/kg体重和氯氰碘柳胺钠注射液10、15 mg/kg体重剂量驱除绵羊肝片吸虫安全高效。驱除绵羊肝片吸虫两种药物的使用剂量,三氯苯咪唑片剂不低于5 mg/kg,氯氰碘柳胺钠注射液不低于10 mg/kg体重。

Eighty sheep aged 6-8 months naturally infected with Fasciola hepatica were used to carry out the experiment on effect of Triclabendazole tablet and Ciosantel injection.The results showed that the negative rate,reductive rate of Fasciola hepatica ova and the deworming rate of adult parasite was 100%by dosage of 5,10 and 15 mg/kg with Triclabendazole tablet.The deworming rate of Fasciola hepatica larvae was 93.9%,100.0%and 100.0%respectively.The negative rate of Fasciola hepatica ova was60.0%,80.0%and 100.0%respectively and the reductive rate was 89.2%,98.2%and 100.0%respectively by dosage of 5,10 and15 mg/kg with Ciosantel injection respectively.The deworming rate of Fasciola hepatica adult was 97.9%,100.0%and 100.0%respectively and larvae was 90.7%,94.3%and 100.0%respectively;Effect of deworming Fasciola hepaticau using Triclabendazole tablet by dosage of 10 mg/kg was not significantly different comparing with the same dosage of controlling Triclabendazole suspension.The sheep with three dosages did not appear abnormal reaction.The experiment proved that 5 mg/kg,10 mg/kg and 15 mg/kg with Triclabendazole tablet and 10 mg/kg and 15 mg/kg with Closantel injecttion were effective and safe for sheep deworming Fasciola hepatic.The dosage of Triclabendazole tablet and Ciosantel injection against Fasciola hepatica in sheep were not less than 5 mg/kg or 10 mg/kg.