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儿童感染性疾病血清铁和铁蛋白的水平分析 被引量:3

Detection of serum iron and ferritin in children with infection diseases
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摘要 目的检测患有感染性疾病儿童和正常保健儿童的血清铁和铁蛋白水平并分析其原因和意义。方法收集70例患有感染性疾病儿童的血清和70名正常保健儿童的血清,采用Ferene比色终点法检测两组儿童血清的铁含量,采用化学发光法检测两组儿童血清铁蛋白含量,采用t检验统计数据。结果患有感染性疾病儿童的血清铁含量明显低于正常保健儿童[(3.543±1.209)μmol/L vs(13.427±6.161)μmol/L],差异有统计学意义(t=-13.172,P<0.01);而血清铁蛋白水平在患有感染性疾病的儿童中明显高于正常保健儿童[(759.471±539.109)ng/ml vs(41.672±19.041)ng/ml],差异有统计学意义(t=11.133,P<0.01)。结论儿童感染时机体存在铁代谢平衡紊乱,出现铁离子重新分布,血清铁明显下降,而铁蛋白则明显升高,可为疾病的诊断和治疗提供参考依据。 Objective To detect the levels of serum iron and ferritin in children with infection diseases and the healthy children. Methods A total of 140 children were divided into two groups : group 1 with 70 infection children,group 2 with 70 healthy children. Serum iron levels in two groups were detected by the method of Ferene endpoint method. While ferritin in two groups were detected by chemoluminescence method. All data were statistically analyzed using the independent-samples t test.Results A statistically significant decrease in serum iron level and increase in serum ferritin level were found in the infection group when compared with the healthy group [iron with(3.543±1.209)μmol / L vs(13.427±6.161)μmol / L,ferritin with(759.471±539.109)ng / ml vs(41.672±19.041)ng / ml]. Conclusion The iron homeostasis was disordered in children with infectious diseases. Iron was redistributed,serum iron was decreased,and ferritin was significantly increased in the children with infectious disease. These changes could be used for the diagnosis and treatment of disease.
出处 《热带医学杂志》 CAS 2015年第10期1384-1386,共3页 Journal of Tropical Medicine
关键词 儿童感染 血清铁 铁蛋白 Infection children Serum iron Ferritin
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