保山市G6PD筛查结果分析

Screening of glucose-6-phosphate dehydrogenase in Baoshan city

目的了解保山市葡萄糖-6-磷酸脱氢酶(G6PD)缺乏情况,为疾病防治和临床诊疗提供参考。方法采用纯化学反应荧光法对8 712例标本进行G6PD缺乏症的筛查。结果 8 712例标本中共筛查出阳性98例,阳性率为1.12%。G6PD筛查阳性率最高为腾冲县2.00%,隆阳区最低为0.43%,各县区差异有统计学意义(χ2=37.34,P<0.01)。男性G6PD缺乏筛查检出率为1.54%,女性为0.43%,差异有统计学意义(χ2=22.40,P<0.01)。回族G6PD筛查检出率最高为3.81%,其次是彝族1.71%,傣族1.63%,最低为布朗族0.70%,不同民族检出率差异有统计学意义(χ2=12.21,P<0.01)。结论保山市人群G6PD缺乏筛查阳性率为1.12%,在病例治疗过程中应做好相应筛查,以防抗疟药及其它药物引起溶血反应。

Objective To understand the situation of glucose-6-phosphate dehydrogenase（G6PD） deficiency in Baoshan city and provide reference for prevention and control,clinical diagnosis and treatment of the disease. Methods Pure chemical reaction fluorescence method was used for screening of G6 PD deficiency in 8 712 samples. Results A total of 98 samples screened were postive for G6 PD deficiency,with a positive rate of 1.12%. Positive rate of Tengchong county was the highest,2.00%,and of Longyang district was the lowest,0.43%. The positive rates between counties were significantly different（ χ2=37. 34,P 0. 01）. The positive rate of male（ 1. 54%） was significantly higher than that of female（ 0. 43%）（ χ2=22.40,P〈0.01）. G6 PD screening in different ethnics showed that the positive rate of Hui ethnic group was the highest（3.81%）,followed by Yi ethnic（1.71%） and Dai ethnic（1.63%）; positive rate of Bulang ethnic（0.70%） was the lowest. The differences among different ethnics were significant（χ2=12.21,P〈0.01）. Conclusion G6 PD deficiency in Baoshan city was 1.12%. In the course of treatment,proper screening should be done to prevent hemolytic reaction caused by anti-malarial drugs.