摘要
The nuclear factor κB （NFκB） transcription factor plays critical roles in inflammation and immunity. The dysregulation of NFKB is associated with inflammatory and autoimmune diseases and cancer. NFKB activation is negatively regulated by the ubiquitin-dependent proteasomal degradation pathway. In the present review, we discuss recent advances in our understanding of how ubiquitin ligases regulate the NFκB degradation pathway.
The nuclear factor κB （NFκB） transcription factor plays critical roles in inflammation and immunity. The dysregulation of NFKB is associated with inflammatory and autoimmune diseases and cancer. NFKB activation is negatively regulated by the ubiquitin-dependent proteasomal degradation pathway. In the present review, we discuss recent advances in our understanding of how ubiquitin ligases regulate the NFκB degradation pathway.
基金
This work was supported by the Jiangsu Province Natural Science Foundation （SBK201320232）
the National Science Foundation of China （ 31271272, 31071030）
and the Scientific Research Foundation for Returned Overseas Chinese Scholars, State Education Ministry.
