医院污水消毒剂溴氯海因泡腾片亚急性经口毒性研究

SUBACUTE ORAL TOXICITY STUDIES OF BCDMH EFFERVESCENT TABLETS FOR HOSPITAL SEWAGE

目的研究医院污水消毒剂溴氯海因泡腾片的亚急性毒性,了解其应用的安全性。方法采用动物试验和生化检验方法进行亚急性毒性评价。结果各试验组动物在染毒期内无死亡。试验末,动物尿常规和血液学检测项目均在本检测单位正常值范围内,与对照组比较差异无统计学意义(p>0.05)。生化检测发现高剂量组动物血清中的谷丙转氨酶(ALT)水平显著升高,此外雄性大鼠血清中的肌酐(CR)含量也显著升高,与对照组比较差异均有统计学意义(p<0.05)。病理组织学检查提示高剂量组动物肝脏出现轻度脂肪变性和点状坏死。结论在剂量水平雄性84 mg/kg,雌性98 mg/kg未观察到溴氯海因泡腾片对SD大鼠的有害作用。

Objective To study subacute oral toxicity of a disinfectant for hospital sewage which contained 1- bromo- 3- chloro- 5,5- dimethylhydantoin（ BCDMH） in order to know about its toxicological safety. Methods Animal test and biochemical examination methods were adopted to evaluate its subacute toxicity. Results During the subacute toxicity test,none of the rats died. At the end of the experiment,urine routine and hematological examination were in the normal ranges. There were no difference compared with the control（ p〈0. 05）. But serum alanine aminotransferase in both sexes as well as creatinine in male SD rats of the high dose group were increased obviously compared with the control（ p〈0. 05）. Mild steatosis and spotty necrosis of liver cells were found in the high dose group during the pathological examination. Conclusion The BCDMH effervescent tablets＇ no- observed- adverse-effect- level（ NOAEL） is 84 mg·kg- 1for male SD rats,and 98 mg·kg- 1for female SD rats.