厄贝沙坦对高血压合并心力衰竭超敏反应蛋白、脑钠肽的影响

THE EFFECT OF IRBESARTAN ON HYPERSENSITIVITY PROTEIN BRAIN NATRIURETIC PEPTIDE OF PATIENTS WITH HYPERTENSION AND HEART FAILURE

目的研究厄贝沙坦治疗高血压合并心力衰竭对超敏反应蛋白(hs-CRP)及脑钠肽(BNP)的影响。方法将我院124例患者抽签随机分为观察组与对照组,两组均为62例,两组均接受降血压等常规治疗;观察组同时口服厄贝沙坦治疗,比较两组临床疗效、BNP、hs-CRP、各体征指标及超声心电图检测结果差异。结果 1两组治疗总有效率93.55%vs 80.65%,观察组显著较高(p<0.05);2治疗后观察组BNP、hs-CRP水平(104.62±22.84)mg/L、(4.68±1.51)mg/L,比对照组(189.50±29.67)mg/L、(7.66±1.72)mg/L显著较低(p<0.05);3治疗后观察组LVDd、LVSd分别为(54.61±4.28)、(40.62±6.17),显著低于对照组(62.61±6.33)、(53.10±7.31),LVEF、FS分别为(49.27±7.44)、(42.30±7.18),显著高于对照组(42.30±7.18)、(16.87±5.06),比较差异有统计学意义(p<0.05);4两组不良反应发生率比较无显著差异(p>0.05)。结论厄贝沙坦治疗高血压合并心力衰竭可显著降低BNP、hs-CRP水平,且临床效果显著,可改善心功能,有临床应用价值。

Objective To study the Irbesartan in treatment of hypertension with heart failure of hypersensitivity protein（ hs- CRP） and the effect of brain natriuretic peptide（ BNP）. Methods 124 patients in our hospital were randomly divided into observation group and control group with draw methods,62 cases of each group. The two groups were accepted blood pressure and other conventional treatment; the observation group at the same time with irbesartan treatment. Two groups of clinical curative effect,the BNP,hs- CRP,various index signs and the ultrasonic cardiogram test Results were compared. Result 1 two groups total effective93. 55% VS 80. 65%,the observation group was significantly higher（ p〈0. 05）; 2 the observation group after treatment the BNP,hs- CRP levels（ 104. 62 ± 22. 84） mg / L、（ 4. 68 ± 1. 51） mg / L was significantly lower（ p〈0. 05）,compared with the control group（ 189. 50 ± 29. 67） mg/L、（ 7. 66 ± 1. 72） mg/L; 3 Observation group after treatment LVDd,LVSd respectively（ 54. 61 ± 4. 28）,（ 40. 62 ± 6. 17） was significantly lower than the control group（ 62. 61 ± 6. 33）,（ 53. 10 ± 7. 31）,and LVEF,FS respectively（ 49. 27 ±7. 44）,（ 42. 30 ± 7. 18） was significantly higher than control group（ 42. 30 ±7. 18）,（ 16. 87 ±5. 06）（ p〈0. 05）; 4 The incidence of adverse effects in two groups had no significant difference（ p〈0. 05）. Conclusion Irbesartan in treatment of hypertension with heart failure can significantly reduce the BNP and hs- CRP levels,improve heart function,and has high clinical value.