超早期经外侧裂入路对基底节区脑出血患者血清髓鞘碱性蛋白及凝血酶的影响分析

THE ANALYSIS OF THE SERUM MYELIN BASIC PROTEIN AND THROMBIN OF PATIENTS WITH BASAL GANGLIA HEMORRHAGE TREATED WITH ULTRA- EARLY APPROACH BY THE LATERAL FISSURE

目的观察分析超早期经外侧裂入路对基底节区脑出血患者血清髓鞘碱性蛋白及凝血酶的影响。方法将80例基底节区脑出血患者随机分为两组,对照组患者40例采用其他入路手术治疗,观察组患者40例采用经外侧裂入路手术治疗。测定两组患者术后第1天、第4天、第7天和第15天的血清髓鞘碱性蛋白(MBP)和凝血酶变化情况,并采用GOS分级评估患者神经系统情况。结果术后第1天和第15天两组患者的血清MBP及凝血酶水平比较差异不明显(p>0.05)。术后第4天和第7天观察组患者的血清MBP及凝血酶水平均明显低于对照组患者(p<0.05)。两组患者术后血清MBP及凝血酶均呈先上升后下降的趋势变化。术后,观察组患者术后GOS分级明显优于对照组患者(p<0.05)。结论超早期经外侧裂入路可有效降低基底节区脑出血患者血清髓鞘碱性蛋白及凝血酶,改善患者神经系统症状,有利于临床治疗。

Objective To observe and analysis the serum myelin basic protein and thrombin of patients with basal ganglia hemorrhage treated with ultra- early approach by the lateral fissure. Methods 80 cases of patients with basal ganglia hemorrhage were randomly divided into two groups. The control group patients（ 40 patients） were treated with other approach surgical treatment while the observation group patients（ 40 patients） were treated by the lateral fissure approach surgery. Serum myelin basic protein（ MBP） and thrombin of patients 1 day,4 days,7 days and 15 days after surgery. Neurological conditions of patients were valued by GOS grading. Results MBP and thrombin serum levels of two groups patients had no significant difference 1 day and 15 days after surgery（ p〈0. 05）.MBP and thrombin serum levels of the observation group patients were lower than those of the control group patients（ p〈0. 05）. MBP and thrombin serum of two groups patients showed a downward trend after the first rise after surgery. GOS grading of the observation group patients were higher than that of the control group patients（ p〈0. 05）. Conclusion Ultra- early approach by the lateral fissure can effectively reduce the serum myelin basic protein and thrombin of patients with basal ganglia hemorrhage treated and improve neurological symptoms. It ＇s clinically beneficial treatment.