多原发结直肠癌21例临床诊疗分析

Clinical analysis of 21 cases of multiple primary colorectal carcinoma

目的探讨研究多原发结直肠癌（MPCC）的临床及诊疗特点。方法回顾本院2006年1月至2013年12月期收治的21例MPCC患者的临床资料,并进行分析总结,同时对所有患者进行随访分析。结果所有患者均采用手术治疗的方式,共行手术切除31例次,其中根治性手术26例次,根治性手术切除率为84%,无围手术期死亡患者。所有患者均获得随访,随访时间1-7年,MPCC患者的2年、5年、7年总体生存率分别为95%、50%、12%,中位生存时间为（4.9±0.4）年。其中同时组和异时组患者的2年、5年、7年生存率分别为91%、42%、10%和100%、75%、38%,异时组患者的总体生存情况优于同时组患者。结论 MPCC患者治疗的关键在于早期发现、早期诊断和早期治疗,最佳治疗方案是及时进行根治性切除。

Objective To explore the diagnosis and therapy method of multiple primary colorectal carcinoma（MPCC）.Methods We retrospectively analyzed the clinical data of 21 MPCC patients between January 2006 and December 2013.Then we followed up all of the patients and analyzed the survival rate.Results All of patients underwent operation.And the radical excision rate was 84%（26/31）.No patient was dead during the peri-operative period.All of the patients were followed up,and the time was 1to 7years.The total survival rate of MPCC patients of 2year,5year and 7year was 95%,50%and 12%,respectively.The average survival time was 4.9±0.4years.The survival rates of synchronous group and metachronous group of 2year,5year and 7year were91%,42%,10% and 100%,75%,38%,respectively.And the survival rate of metachronous group was better than that of synchronous group.Conclusion The key points to treat MPCC are early detection,early diagnosis and early treatment.And the best therapy method was radical excision of the carcinoma.