非酒精性脂肪性肝病与动脉粥样硬化关联性的研究进展

Research on advances of the relationship between nonalcoholic fatty liver disease and atherosclerosis

非酒精性脂肪性肝病(NAFLD)是与遗传易感性和胰岛素抵抗(IR)密切相关的代谢应激性肝病,目前亦认为是代谢综合征(MS)的肝脏表现,常常与肥胖、2型糖尿病、高血压病、高脂血症以及MS等合并存在。近年来,NAFLD的患病率逐年增高,并且在2型糖尿病、肥胖患者中其患病率更高。动脉粥样硬化(AS)是心血管疾病(CVD)的基础,而目前研究发现NAFLD与CVD关系密切,NAFLD患者主要死亡原因是CVD和恶性肿瘤,NAFLD与AS关系亦密切,其机制目前仍不明确,可能涉及到胰岛素抵抗、血脂代谢紊乱、氧化应激、炎症反应、脂肪激素水平变化和肝功能等方面。本文就NAFLD和AS间的相关性及可能机制进行综述。

Nonalcoholic fatty liver disease （NAFLD）, a metabolic stress-induced liver disease, is closely related to genetic susceptibility and insulin resistance （IR）. It represents hepatic manifestation of metabolic syndrome （MS）, and is associated with obesity, type 2 diabetes, hypertension, dyslipidemia, and metabolic syndrome. The prevalence of NAFLD increased year by year, and it is higher in the patients with type 2 diabetes and obesity. Atherosclerosis （AS） is the basic of cardiovascular disease （CVD）, it is found that NAFLD was closely associated with CVD, and NAFLD was the cause of death in patients with CVD and malignant tumor. Also, there is a closely relationship between NAFLD and AS. The mechanism is not clear, and it may be related to insulin resistance, atherogenic dyslipidemia, oxidative stress, inflammation, the changes of fat hormone level and function in liver cell, etc. In this article, the relationship and possible mechanism between NAFLD and AS were reviewed.