摘要
目的 :针对云南曲靖地区宣威县、富源县及非曲靖地区 3组正常人群进行GSTM1基因型多态性的比较研究。方法 :采用聚合酶链反应 (Polymerasechainreaction ,PCR)技术对相关人群进行基因型鉴定。结果 :GSTM1纯合缺失基因型 (0 /0 )的频率在宣威人群为 6 3.6 %(n =33) ,富源人群为 6 4.5 %(n =31) ,非曲靖人群为 6 8.5 %(n =35 )。结论 :GSTM1基因型多态性在 3个正常人群中的分布情况均一。该研究为了解特定地区肺癌与外源物代谢解毒基因之间的可能联系提供了一些基础数据。
Purpose: To compare the genetic polymorphism of glutathione S-transferase M1 (GSTM1) locus between the populations in Xuanwei and Fuyuan counties in Qujing city and between Qujing and non-Qujing residents in Yunnan province. Methods: Polymerase chain reaction (PCR) was employed to justify the genotype of the aim population. Results: No significant difference was found in the GSTM1 genotype frequencies among those three groups (P>0.05), i.e., the frequencies of GSTM1 null genotype (0/0) were 63.6% in Xuanwei residents, 64.5% in Fuyuan group and 68.5% in non-Qujing group, respectively. Conclusion: Among the normal populations studied, the genetic polymorphism distribution of GSTM1 genes was proved to be homogenous. The result is helpful for further research on the association on lung cancer and xenobiotics detoxification genes.
出处
《癌变．畸变．突变》
CAS
CSCD
2002年第1期22-24,共3页
Carcinogenesis,Teratogenesis & Mutagenesis
基金
云南省自然科学基金 ( 2 0 0 0C0 0 46M)
