全雄激素阻断治疗对前列腺癌老年患者认知功能的影响探讨

Whole androgen depriation therapy effects on cognitive function in elderly patients with prostate cancer

目的探讨在老年前列腺癌患者的治疗中使用全雄激素阻断的方法对老年患者的认知功能的影响。方法选取我院2012—02—2015—02收治的惠有前列腺癌的50例老年患者，随机分为实验组与参照组，每组25例，对实验组患者施行全雄激素阻断治疗，参照组患者施行前列腺癌根治术治疗，在治疗结束后对两组患者的认知功能进行测试并比较。结果其中睾酮含量、记忆评分、注意评分、视空间及执行力以及MOCA评分总分实验组均明显低于参照组，P〈0．05。其余项目实验组与参照组差异均无统计学意义，P〉0．05。结论将全雄激素应用于老年患者的前列腺癌治疗会对患者的认知功能造成一定的损害，尤其是记忆、注意、视空间以及执行力方面的损害较为明显，实验证明，这种损害与患者体内的睾酮含量变化相关，睾酮含量越低，患者的认知功能受损情况就越为严重。

OBJECTIVE To explore the use of androgen deprivation approach in the treatment of eIcterly panenrs with prostate cancer, the impact on cognitive function in elderly patients. METHODS 50 cases of elderly patients in our hospital in February 2012 and February 2015 were treated with prostate cancer, they were randomly divided into the ex- perimental group and the reference group, 25 cases in each group, the experimental group underwent full androgen depri- vation therapy, for the reference group underwent radical prost^teetomy treatment, after treatment on cognitive {unction of two groups of patients were tested and compared. RESULTS Where testosterone, and memory scores, note score, visuospatial and executive power and MoCA total score of these items in the experimental group were significantly lower than the reference group, the differences are to meet P〈10.05, and therefore statistically meaningful difference ~ The re- maining items in the experimental group and the reference group little difference, P：〉0.05, the difference was not statis- tically significant. CONCLUSION The hormonal treatment of prostate cancer will be applied to the patient＇s cognitive function in elderly patients cause some damage, especially memory, attention, visuospatial and executive ability damage is more obvious, the experiment proved that the damage and testosterone-related changes in the patient＇s body, the lower testosterone levels and cognitive function in patients with more serious damage.