小剂量环孢素联合左旋咪唑治疗再生障碍性贫血临床价值探析

Small doses of ring spore element joint levamisole treatment of aplastic anemia clinical value

目的探讨小剂量环孢素与左旋咪唑联合应用于治疗再生障碍性贫血的，临床疗效。方法收集延安大学附属医院2013-012015-01收治的再生障碍性贫血患者96例，随机分为试验组与对照组各48例。对照组予以常规剂量环孢素5mg／（kg·d）治疗，试验组予以小剂量环孢素2mag／（kg·d）联合左旋咪唑100mg／d治疗，对比两组的治疗效果。结果试验纽的治疗总有效率为81．25％，高于对照组的75．00％；两组治疗后血红蛋白（Hb）及中性粒细胞（NEUT）均显著提高，P〈0．05；对照组的血小板计数（PLT）显著降低，而试验组显著提高，P〈0．05；试验组的不良反应率为2．08％，显著低于对照组的37．50％，P〈0．05。结论小剂量环孢素与左旋咪唑联合应用于治疗再生障碍性贫血具有显著疗效，且可减少环孢素用量及其不良反应，改善临床预后，值得推广应用。

OBJECTIVE To study the small dose of ring spore element and levamisole combined application in the clinical curative effect for the treatment of aplastic anemia. METHODS collecting 96 eases of aplastic anemia patients of our hospital were randomly divided into experimental group and control group （n= 48）. Control group to regular doses of ring spore treatment, the treatment group to low-dose ring spore joint levamisole 100 mg/d treatment, compared two groups of treatment effect. RESULTS Treatment group total effective rate of 81.25% ,and 75.00% in the control group there was no significant difference; Two groups of Hb and NEUT are significantly improved after treatment （P〈0.05）, no significant differences between groups （P〉0.05）. CONCLUSION small dose of ring spore element and levamisole combined application in the treatment of aplastic anemia has significant curative effect,and can reduce ring spore consump- tion and its side effects, improve clinical outcomes.