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不同卵巢癌HOXA-10和PTEN及p53的特异性表达差异及意义 被引量：2

Different ovarian cancer HOXA-10, specific expression and significance of PTEN and p53
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摘要 目的比较透明细胞癌合并子宫内膜异位症，卵巢子宫内膜样癌合并子宫内膜异位症，为临床特殊合并症的诊断及治疗提供依据。方法选取2010—12—2014—12患者共i00例，应用免疫组化技术检测各组PTNE、HOXA-10和p53的表达情况。结果PTEN在正常妇女、单纯子宫内膜异位症、卵巢透明细胞癌和透明细胞癌合并子宫内膜异位症患者及卵巢子宫内膜样癌合并子宫内膜异位症中的表达逐渐降低。结论PTEN突变与表达缺失与卵巢癌发生发展有关，PTEN蛋白低表达和卵巢癌的侵袭、转移有关。 OBJECTIVE To compare the clear cell carcinoma combined endometriosis, endometrial carcinoma of o- vary endometriosis merger, provide the basis for clinical diagnosis and treatment of complications after special. METH- ODS Choose 100 cases, application testing each PTNE immunohistochemical techniques, HOXA-10 and the expression of p53. RESULTS PTEN in normal women, pure endometriosis and ovarian clear cell carcinoma, clear cell carcinoma of the merger in patients with endometriosis, endometrial carcinoma of ovary merger of endometriosis express gradually re- duced. CONCLUSION The loss of PTEN mutation and expression is associated with ovarian cancer development, low PTEN protein expression and the invasion and metastasis of ovarian cancer.
作者 范小华 程文俊
机构地区 南京医科大学第一附属医院妇产科 镇江市第四人民医院妇产科
出处 《中华肿瘤防治杂志》 CAS 北大核心 2015年第B22期44-45,共2页 Chinese Journal of Cancer Prevention and Treatment
关键词 卵巢癌 子宫内膜异位症 PTEN基因 HOXA-10 P53 ovarian cancer endometriosis PTEN gene HOXA-10 p53
分类号 R737.3 [医药卫生—肿瘤]
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参考文献6

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二级参考文献11

  • 1郎景和.子宫内膜异位症研究的新里程[J].中华妇产科杂志,2005,40(1):3-4. 被引量：279
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中华肿瘤防治杂志
2015年 第B22期

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