血清RF、抗CCP抗体和抗MCV抗体水平对早期类风湿关节炎的诊断价值

The diagnostic value of rheumatoid factor,serum anti ring citrulline peptide and Anti-Mutated citrullinated vimentin antibodies to early rheumatoid arthritis

目的探讨抗突变型瓜氨酸波形蛋白(MCV)抗体对早期类风湿关节炎(RA)的诊断价值。方法选择2012年5月-2014年4月我院收治的早期RA患者50例为早期RA组,选择同期于我院就诊的非RA患者30例为非RA组,另选择同期于我院健康查体者30例作为对照组。检测所有受试者血清类风湿性因子(RF)、抗环瓜氨酸肽(CCP)抗体和抗MCV抗体水平,对比分析三种检测指标诊断早期RA的敏感性和特异性,分析三者的相关性。结果早期RA组和非RA组血清RF、抗CCP抗体、抗MCV抗体水平均显著高于对照组,早期RA组血清RF、抗CCP抗体和抗MCV抗体水平高于非RA组,差异均有统计学意义(P<0.05);早期RA组RF、抗CCP抗体和抗MCV抗体阳性率均高于非RA组和对照组,早期RA组抗MCV抗体阳性率显著高于RF、抗CCP抗体阳性率,差异均有统计学意义(P<0.05);抗MCV抗体诊断早期RA的敏感性和特异性分别为82.00%和92.00%,显著高于RF和抗CCP抗体的敏感性和特异性,差异有统计学意义(P<0.05)。Pearson相关分析显示,抗MCV抗体与抗CCP抗体、RF均呈显著正相关(P<0.05)。结论抗MCV抗体、抗CCP抗体和RF在早期RA患者血清中高表达,抗MCV抗体诊断早期RA的敏感性和特异性均较高,可以作为早期RA的辅助诊断方法。

Objective To explore the diagnostic value of Anti-Mutated citrullinated vimentin antibodies to early rheumatoid arthritis. Methods Chose 50 cases early RA patients from our hospital in May 2012-April 2014 set for early RA group,chose the same period in our hospital of 30 cases no RA patients set for the no RA group,chose 30 healthycheck-up people as healthy controls in the same period in our hospital. Testing all subjects rheumatoid factor （RF）, serum anti ring citrulline peptide （CCP） antibody, fight the MCV antibody levels, contrast analysis of three kinds of test indexes sensitivity and specificity in the diagnosis of early RA,analysis the correlation of the three. Results The levels of Anti-MCV antibodies, Anti-CCP antibodies and RF in Early RA group and the no RA group were significantly higher than that of healthy controls,he early RA group were significantly higher than that of higher than the RA group, the difference has statistical significance （P〈0. 05）, The positive rate of Anti-MCV antibodies,Anti-CCP antibodies and RF in Early RA group were higher than in the RA group and healthy controls,the early RA group had a significantly higher rate of positive of antibody of MCV resistance RF,anti CCP antibody positive rate,differences were statistically significant （P〈0.05） ; Resist the MCV antibodies in the diagnosis of early RA sensitivity and specificity were 82.00% and 92.00 % respectively,significantly higher than that of the RF and the sensitivity and specificity of CCP antibody, the difference was statistically significant （P〈0.05） ; Pearson correlation analysis showed that the MCV antibody resistance and anti CCP antibody and RF were significant positive correlation （P〈0.05）. Conclusion Anti-MCV antibodies, Anti-CCP antibodies and RF in patients with early RA are high serum expression, the sensitivity and specificity of Anti-MCV antibodies to the diagnosis of early RA is high,and can be used as auxiliary diagnosis of early RA.