摘要
目的探讨甲胎蛋白(AFP)、甲胎蛋白异质体-L3(AFP-L3)、高尔基体蛋白73(GP73)在原发性肝癌的诊断价值。方法采用酶联免疫吸附法和电化学发光法检测68例原发性肝癌、49例良性肝病及68例健康体检者血清中AFP、AFP-L3、GP73的含量,并进行比较。结果原发性肝癌患者组血清AFP、AFP-L3、GP73含量明显高于良性肝病及健康对照组(P<0.05和P<0.01);三者联合检测的特异度和敏感度优于单独检测,所得数据有统计学意义。结论 AFP、AFP-L3、GP73联合检测可明显提高原发性肝癌诊断的敏感性和特异性。
Objective To investigate the application value of detection AFP, AFP-L3 and GP73 in the diagnosis of hepatocellular carcinoma. Methods Enzyme-linked immunosorbent assay （EL1SA） was adopted to detect AFP.AFP- L3 and GP73 level of senum in hepatocellular carcinoma patients（68cases）,benign liver disease （49 cases） and healthy people （68cases） ,and comparison was done. Results the Serum AFP,AFP-L3 and GP73 level in hepatocellular carcinoma were significantly higher than those of patients with benign liver diseases and control group （P〈0. 05, P〈 0.01）. The specificity and sensitivity of the combined detection of the three was better than that of the individual test, and the difference was statistically significant. Conclusion Combination test of serum AFP, AFP-L3 and GP73 has good diagrnosis value for hepatocellular carcinoma
出处
《中国实验诊断学》
2015年第11期1901-1903,共3页
Chinese Journal of Laboratory Diagnosis
