摘要
目的:探讨体素内不相干运动扩散加权成像(IVIM-DWI)各相关参数在正常前列腺组织中的可重现性,并分析其随年龄的变化趋势。材料与方法将66名符合纳入标准的各年龄段健康志愿者分成三组(A组,15~30岁,13名;B组,31~50岁,25名;C组,≥51岁,28名),在3.0 T磁场强度下对志愿者行IVIM-DWI扫描,休息30 min后行第二次IVIM-DWI扫描(b值0、25、50、75、100、150、200、400、600、800、1000、1200、1500、2000、3000 s/mm2),应用双指数模型对信号衰减进行分析得出slow ADC值,fast ADC值及f值。采用配对样本t检验研究前后两次扫描之间的差异,探讨各参数的可重现性;采用方差分析(ANOVA)及LSD法对各参数在不同年龄段正常前列腺组织中的差异进行比较,分析其随年龄的变化趋势。结果 A组健康志愿者前列腺中央腺fast ADC值两次测量数据差异有统计学意义(P=0.022),其余各参数两次测量数据差异没有统计学意义;slow ADC值外周带A、B组及A、C组间差异有统计学意义,B、C组间差异无统计学意义,中央腺A、C组及B、C组间差异有统计学意义,A、B组间差异无统计学意义;fast ADC值外周带及中央腺各组两两间均无显著性差异;f值外周带各组两两间均有显著性差异,中央腺A、C组及B、C组间差异有统计学意义,A、B组间差异无统计学意义;前列腺外周带及中央腺slow ADC值、f值总体上随年龄段升高呈上升趋势。结论不同年龄段正常前列腺组织的IVIM-DWI各相关参数总体上具有良好的可重现性;应用影像学手段,通过对IVIM-DWI相关参数的分析,可以定量的反映前列腺随年龄升高而发生的各种细胞水平的变化,为前列腺疾病的诊断及定量分析提供可靠的依据。
Objective:To investigate the reproducibility of the intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) derived parameters, and analyze the change of the IVIM-DWI derived parameters of normal prostate in different age groups. Materials and Methods:Sixty-six volunteers conformed to the standards were divided into three groups (group A, 15—30 years, 13. Group B, 31—50 years, 25. Group C,≥51 years, 28) and underwent the scanning of IVIM-DWI with 15 b-factors from 0 to 3000 (0, 25, 50, 75, 100, 150, 200, 400, 600, 800, 1000, 1200, 1500, 2000, 3000 s/mm2) twice with an interval of 30 minutes using 3.0 T MRI device, the biexponential ifts were applied to ifgure out the slow ADC, fast ADC and f values. The reproducibility of every parameters were investigated by the paired t-test. The differences of every parameters in normal prostate between the three age groups were assessed using one-way analysis of variance (ANOVA) and the least significant difference (LSD) t-test. Results: Slow ADC, fast ADC and f values showed good reproducibility in both peripheral zone (PZ) and central gland (CG) of three age groups, except fast ADC in CG of group A (P=0.022). The slow ADC and f values of the prostate peripheral zone and central gland had the upward tendency with age increasing. Slow ADC showed signiifcant difference between group A and B, group A and C, while had no signiifcant difference between group B and C in PZ, and slow ADC showed signiifcant difference between group A and C, group B and C, while had no signiifcant difference between group A and B in CG. Fast ADC in both PZ and CG between three age groups had no signiifcant different. F value show signiifcant difference between three age groups in PZ, while in CG f value show signiifcant difference between group A and C, group B and C, while had no signiifcant difference between group A and B. Conclusions:In general, a good reproducibility of IVIM-DWI derived parameters in normal prostate of three age groups was observed. IVIM-DWI technology relfected the age-related change of prostate tissues in the celluar level, and the derived parameters could set a reliable reference to the quantitative analysis of prostate diseases.
出处
《磁共振成像》
CAS
CSCD
2015年第11期848-854,共7页
Chinese Journal of Magnetic Resonance Imaging
基金
广东省社会发展领域科技计划项目(编号2013B021800161)
关键词
前列腺
磁共振成像
年龄因素
Prostate
Magnetic resonance imaging
Age factors