摘要
目的系统评价肿瘤坏死因子α诱导蛋白3相互作用蛋白1(TNFα-induced prote in 3-interacting protein1,TNIP1)基因与系统性红斑狼疮(systemic lupus erythematosus,SLE)的相关性。方法计算机检索PubMed、WebofScience和EMbase,查找关于TNIP1基因rs7708392或rs10036748位点多态性与SLE相关性的病例一对照研究,检索时间至2015年2月;由2名评价员按照纳入和排除标准独立进行文献筛选、资料提取和质量评价后,采用Stata12.0软件进行Meta分析。结果共纳入12篇研究文献,其中关于TNIP1基因rs7708392位点多态性与SLE的病例一对照研究10个,关于TNIP1基因rs10036748位点多态性与SLE的病例一对照研究6个。Meta分析结果显示,病例组TNIP1基因rs7708392位点等位基因C频率高于对照组(OR=1.23,95%a:1.12—1.34,P〈0.001);病例组TNIPl基因rs10036748位点等位基因T频率高于对照组(OR=1.29,95%C/:1.24—1.34,P〈0.001);按照种族分层分析结果显示,欧洲人群TNIP1基因rs7708392位点C:T的OR值为1.29(95%C/:1.23~1.35),亚洲人群C:T的OR=1.14(95%C/:0.92~1.42);亚洲人群TNIP1基因rs10036748位点T:C的OR为1.25(95%C/:1.18~1.33)。结论TNIP1基因rs7708392位点C等位基因、rs10036748位点T等位基因与系统性红斑狼疮遗传易感性相关,TNIP1基因上述位点基因型有可能成为早期诊断系统性红斑狼疮的指标。
Objective To perform a more accurate estimation of association between systemic lupus erythematosus (SLE) and TNFα-induced protein-3-interacting protein 1 (TNIP1). Methods Data were searched from PubMed, EM- BASE, and Web of science and from others medical databases. All the data were collected from published articles before Feb- ruary 2015. According to the inclusion and exclusion criteria, two reviewers independently screened literatures, extracted da- ta, and evaluated the quality of studies. The Meta-analysis was performed using the STATA 12. 0 software. Results The a- nalysis included 12 articles, consisting of 10 case-control studies related to the TNIP1 gene rs7708392 polymorphisms and 6 case-control studies related to the TNIP1 gene rs10036748 polymorphisms. Our meta-analysis revealed significantly increased frequency of the C allele of TNIP1 rs7708392 frequency in the case group was higher than that in the control group ( OR = 1.23, 95% CI:1. 12-1.34, P 〈0. 001 ) and the T allele of TNIP1 rs10036748 frequency in the case group was higher than that in the control group ( OR = 1.29, 95% CI: 1.24-1.34, P 〈0. 001 ). In the subgroup analysis by ethnicity, the results in- dicated that in TNIP1 rs7708392, the OR of the C:T ratio was 1.29 (95% CI:1. 23-1.35) in European populations and 1.14 (95% CI:0. 92-1.42) in Asian populations. In the TNIP1 gene rs10036748, the OR of the T: C ratio was 1.25 (95% CI: 1.18-1.33) in Asian populations. Conclusions The TNIP1 rs7708392 C allele and the rs10036748 T allele are significantly associated with genetic susceptibility to SLE, and may act as indicators for early diagnosis.
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2015年第11期1152-1157,共6页
Chinese Journal of Disease Control & Prevention
基金
国家自然科学基金(81470070)