系统性红斑狼疮(SLE)与TNIP1基因相关性的Meta分析

A Meta-analysis of the association of SLE with TNIP1 polymorphisms

目的系统评价肿瘤坏死因子α诱导蛋白3相互作用蛋白1（TNFα-induced prote in 3-interacting protein1，TNIP1）基因与系统性红斑狼疮（systemic lupus erythematosus，SLE）的相关性。方法计算机检索PubMed、WebofScience和EMbase，查找关于TNIP1基因rs7708392或rs10036748位点多态性与SLE相关性的病例一对照研究，检索时间至2015年2月；由2名评价员按照纳入和排除标准独立进行文献筛选、资料提取和质量评价后，采用Stata12．0软件进行Meta分析。结果共纳入12篇研究文献，其中关于TNIP1基因rs7708392位点多态性与SLE的病例一对照研究10个，关于TNIP1基因rs10036748位点多态性与SLE的病例一对照研究6个。Meta分析结果显示，病例组TNIP1基因rs7708392位点等位基因C频率高于对照组（OR=1．23，95％a：1．12—1．34，P〈0．001）；病例组TNIPl基因rs10036748位点等位基因T频率高于对照组（OR=1．29，95％C／：1．24—1．34，P〈0．001）；按照种族分层分析结果显示，欧洲人群TNIP1基因rs7708392位点C：T的OR值为1．29（95％C／：1．23～1．35），亚洲人群C：T的OR=1．14（95％C／：0．92～1．42）；亚洲人群TNIP1基因rs10036748位点T：C的OR为1．25（95％C／：1．18～1．33）。结论TNIP1基因rs7708392位点C等位基因、rs10036748位点T等位基因与系统性红斑狼疮遗传易感性相关，TNIP1基因上述位点基因型有可能成为早期诊断系统性红斑狼疮的指标。

Objective To perform a more accurate estimation of association between systemic lupus erythematosus （SLE） and TNFα-induced protein-3-interacting protein 1 （TNIP1）. Methods Data were searched from PubMed, EM- BASE, and Web of science and from others medical databases. All the data were collected from published articles before Feb- ruary 2015. According to the inclusion and exclusion criteria, two reviewers independently screened literatures, extracted da- ta, and evaluated the quality of studies. The Meta-analysis was performed using the STATA 12. 0 software. Results The a- nalysis included 12 articles, consisting of 10 case-control studies related to the TNIP1 gene rs7708392 polymorphisms and 6 case-control studies related to the TNIP1 gene rs10036748 polymorphisms. Our meta-analysis revealed significantly increased frequency of the C allele of TNIP1 rs7708392 frequency in the case group was higher than that in the control group （ OR = 1.23, 95% CI：1. 12-1.34, P 〈0. 001 ） and the T allele of TNIP1 rs10036748 frequency in the case group was higher than that in the control group （ OR = 1.29, 95% CI： 1.24-1.34, P 〈0. 001 ）. In the subgroup analysis by ethnicity, the results in- dicated that in TNIP1 rs7708392, the OR of the C：T ratio was 1.29 （95% CI：1. 23-1.35） in European populations and 1.14 （95% CI：0. 92-1.42） in Asian populations. In the TNIP1 gene rs10036748, the OR of the T： C ratio was 1.25 （95% CI： 1.18-1.33） in Asian populations. Conclusions The TNIP1 rs7708392 C allele and the rs10036748 T allele are significantly associated with genetic susceptibility to SLE, and may act as indicators for early diagnosis.