分期序贯疗法治疗溃疡性结肠炎68例

Sixty-Eight Patients with Ulcerative Colitis Treated with Sequential Therapy by Stages

目的:观察分期序贯疗法治疗溃疡性结肠炎的疗效。方法:选取溃疡性结肠炎患者127例,按照单盲、平行、随机对照原则分为观察组68例和对照组59例。两组患者根据病情严重程度分别给予不同的西医治疗方案,观察组另给予分期序贯疗法治疗。结果:观察组临床症状评分均优于对照组(P<0.05);观察组血清TNF-α、IL-17及IL-23水平均优于对照组(P<0.05);观察组有效率为89.7%,对照组有效率为71.1%,观察组优于对照组(P<0.05);两组不良反应发生率比较,无显著差异(P>0.05)。结论:分期序贯疗法治疗溃疡性结肠炎疗效显著,能显著改善患者临床症状和血清炎性因子水平。

Objective： To observe the therapeutic effects of sequential therapy by Stages on ulcerative colitis （UC）. Methods： 127 cases with UC were divided into observation group （68 cases） and control group （59 cases） according to the single bland, paral- lel and random principles. The two groups were given different western medicine therapeutic schedules based on the severity, while observation group were additionally given sequential therapy by stages. Results ： The clinical symptom scores of observation group were better than these of control group （ P 〈 0.05）. The levels of serum TNF-α, IL-17 and IL-23 in observation group were better than these in control group （ P 〈 0.05 ）. The effective rate （ 89.7% ） of observtion group was higher than that （ 71.1% ） of control group （ P 〈 0. 05 ）. There was no significant difference between the adverse reactions of the two group （ P 〉 0. 05 ）. Conclusion： Sequential therapy by stages has remarkable therapeutic effects on UC, which can significantly improve the patients＇ clinical symptoms and the levels of serum inflammatol7 cytokines.