摘要
目的:观察分期序贯疗法治疗溃疡性结肠炎的疗效。方法:选取溃疡性结肠炎患者127例,按照单盲、平行、随机对照原则分为观察组68例和对照组59例。两组患者根据病情严重程度分别给予不同的西医治疗方案,观察组另给予分期序贯疗法治疗。结果:观察组临床症状评分均优于对照组(P<0.05);观察组血清TNF-α、IL-17及IL-23水平均优于对照组(P<0.05);观察组有效率为89.7%,对照组有效率为71.1%,观察组优于对照组(P<0.05);两组不良反应发生率比较,无显著差异(P>0.05)。结论:分期序贯疗法治疗溃疡性结肠炎疗效显著,能显著改善患者临床症状和血清炎性因子水平。
Objective: To observe the therapeutic effects of sequential therapy by Stages on ulcerative colitis (UC). Methods: 127 cases with UC were divided into observation group (68 cases) and control group (59 cases) according to the single bland, paral- lel and random principles. The two groups were given different western medicine therapeutic schedules based on the severity, while observation group were additionally given sequential therapy by stages. Results : The clinical symptom scores of observation group were better than these of control group ( P 〈 0.05). The levels of serum TNF-α, IL-17 and IL-23 in observation group were better than these in control group ( P 〈 0.05 ). The effective rate ( 89.7% ) of observtion group was higher than that ( 71.1% ) of control group ( P 〈 0. 05 ). There was no significant difference between the adverse reactions of the two group ( P 〉 0. 05 ). Conclusion: Sequential therapy by stages has remarkable therapeutic effects on UC, which can significantly improve the patients' clinical symptoms and the levels of serum inflammatol7 cytokines.
出处
《河南中医》
2015年第11期2731-2733,共3页
Henan Traditional Chinese Medicine
基金
宝鸡市2013年科学技术研究发展计划项目(编号:13SF4_2)
关键词
溃疡性结肠炎
分期序贯疗法
血清炎性因子
ulcerative colitis (UC)
sequential therapy by stages
serum inflammatory cytokines