加味逍遥散对心理应激性失眠患者焦虑抑郁及睡眠质量的影响

Influence of Supplemented Free-Wandering Powder on Anxiety,Depression and Sleeping Quality of Psychological Stress Insomniacs

目的:观察加味逍遥散对心理应激性失眠患者焦虑抑郁的调节及睡眠质量的影响。方法:选取2012年1月—2014年6月本院收治的120例心理应激性失眠患者为研究对象,随机平均分为观察组与对照组各60例。对照组给予舒乐安定联合加味逍遥散安慰剂治疗,观察组给予加味逍遥散联合舒乐安定治疗,比较两组患者焦虑抑郁以及睡眠质量的改善情况。结果:两组患者治疗后用焦虑自评量表(SAS)和抑郁自评量表(SDS)评分均较治疗前有明显降低(P<0.05),且观察组患者较对照组SAS和SDS评分降低更为明显,两组比较差异有统计学意义(P<0.05);观察组患者主观睡眠质量匹茨堡睡眠指数量表(PSQI)评分及睡眠状况自评量表(SRSS)评分均较对照组患者有明显下降,两组比较差异有统计学意义(P<0.05);观察组患者客观睡眠质量评价指标睡眠效率、总睡眠时间均较对照组有显著性升高,两组比较差异有统计学意义(P<0.05),而Ⅰ期睡眠、Ⅱ期睡眠、睡眠潜伏期、快动眼睡眠相、慢波睡眠以及长短觉醒次数较对照组患者无明显差异,两组比较差异无统计学意义(P>0.05)。结论:加味逍遥散联合舒乐安定治疗心理应激性失眠能够更好的缓解和改善患者的焦虑抑郁情况,疗效显著。

Objective： To observe the influence of Supplemented Free-Wandering Powder on anxiety, depression and sleeping quality of psychological stress insomniacs. Methods ： 120 cases with psychological stress insomniacs received by this hospital from January. of 2012 to June of 2014 were selected as study objects and randomized into observation group and control group, with 60 cases in each group. Control group were given estazolam combined with placebo of Supplemented Free-Wandering Powder for the treatment while observation group were given Supplemented Free-Wandering Powder combined with estazolam for the treatment. The improvements in anxiety, depression and sleeping quality of both groups were compared. Results： The scores of SAS and SDS in both groups declined obviously compared with before the treatment （ P 〈 0.05 ） , and the decline in observation group was much more apparently ; the difference between the two groups had statistical significance （P 〈 0. 05 ）. The PSQI and SRSS scores of ob- servation group decreased when compared with these in control group; the difference between the two groups had statistical signifi- cance （ P 〈 0.05 ）. The evaluation indexes such as sleeping efficiency and total sleeping time of sleeping quality in observation group increased remarkably when compared with these in control group; the difference between the two groups had statistical sig- nificance （P 〈 0.05）. And the I phase, Ⅱ phase, sleeping incubation period, rapid-eye-movement sleep, slow-wave sleep and awakening frequency in observation group had no significant differenee compared with these in control group; the difference had no statistical significance （ P 〉 0.05 ）. Conclusion ： Supplemented Free-Wandering Powder combined with estazolam can better re- lieve anxiety and improve depression of psychological stress insomniacs.