限食治疗糖尿病肾病的研究进展

Effects of diet restriction on diabetic nephropathy

糖尿病肾病是一类十分常见的糖尿病微血管并发症,也是糖尿病致残、致死的主要原因之一.大量的基础和临床研究证实,不同的饮食限制如低蛋白限食、低热量限食及限食模拟剂能够减少蛋白尿的产生、提高肾小球滤过率,防止肾结构改变,以延缓糖尿病肾病的进展,但其具体机制是否与增强自噬、抗氧化应激、抗凋亡相关尚待进一步研究.

Diabetic nephropathy is one of the most common complications of diabetic microangiopathy and the leading causes of death in patients with diabetes.Clinical and basic experiments demonstrated that different types such as calorie or protein restriction and analogue of calorie restriction can reduce the albuminuria, improve glomerular filtration rate, prevent the destruction of the renal construction and delay the progression of diabetic nephropathy.However, the mechanisms of diet restriction, which may be associated with enhanced autophagy or anti-oxidative stress and anti-apoptosis,still need further research.