多聚ADP核糖聚合酶-1与糖尿病肾病

Poly（ADP-ribose） polymerase-1 and diabetic nephropathy

多聚ADP核糖聚合酶-1（PARP-1）是多聚ADP核糖聚合酶家族中重要的成员之一,在肾组织中广泛表达.近期研究发现,PARP-1与糖尿病肾病的发生、发展关系密切,PARP-1通过加重高糖氧化应激、促进慢性低度炎性反应、抑制组蛋白脱乙酰酶-1活性、增强Toll样受体4活性、上调内皮素及内皮素受体的表达、诱导纤溶系统紊乱等参与糖尿病肾病的病理生理过程.而相关研究也证明PARP-1抑制剂在糖尿病肾病的发病过程中可起到一定的保护作用,故PAPR-1可能成为糖尿病肾病的新治疗靶点.

As one of the important members of the poly （ADP-ribose） polymerase family, poly （ADP-ribose）polymerase-1 （PARP-1） is abundantly expressed in renal tissue.Recent studies have shown that there is a close relationship between PARP-1 and diabetic nephropathy.PARP-1 is involved in the pathologic process of diabetic nephropathy by increasing oxidative stress, promoting chronic low-grade inflammation, inhibiting Sirtuin-1 activity, enhancing Toll like receptor 4 activity, boosting endothelin and endothelial receptor as well as disordering fibrinolysis system.Related studies also have shown that PARP-1 inhibitors may play protective roles in the pathogenesis of diabetic nephropathy, which may be a new therapeutic target for diabetic nephropathy.