摘要
多聚ADP核糖聚合酶-1(PARP-1)是多聚ADP核糖聚合酶家族中重要的成员之一,在肾组织中广泛表达.近期研究发现,PARP-1与糖尿病肾病的发生、发展关系密切,PARP-1通过加重高糖氧化应激、促进慢性低度炎性反应、抑制组蛋白脱乙酰酶-1活性、增强Toll样受体4活性、上调内皮素及内皮素受体的表达、诱导纤溶系统紊乱等参与糖尿病肾病的病理生理过程.而相关研究也证明PARP-1抑制剂在糖尿病肾病的发病过程中可起到一定的保护作用,故PAPR-1可能成为糖尿病肾病的新治疗靶点.
As one of the important members of the poly (ADP-ribose) polymerase family, poly (ADP-ribose)polymerase-1 (PARP-1) is abundantly expressed in renal tissue.Recent studies have shown that there is a close relationship between PARP-1 and diabetic nephropathy.PARP-1 is involved in the pathologic process of diabetic nephropathy by increasing oxidative stress, promoting chronic low-grade inflammation, inhibiting Sirtuin-1 activity, enhancing Toll like receptor 4 activity, boosting endothelin and endothelial receptor as well as disordering fibrinolysis system.Related studies also have shown that PARP-1 inhibitors may play protective roles in the pathogenesis of diabetic nephropathy, which may be a new therapeutic target for diabetic nephropathy.
出处
《国际内分泌代谢杂志》
2015年第6期409-412,共4页
International Journal of Endocrinology and Metabolism
基金
辽宁省高等学校“高端人才队伍建设工程”(2014187)
2011年辽宁省“百千万人才工程”资助项目(2011377)
辽宁省科技攻关计划项目(2011225017)