进展期胃癌术后早期循环式腹腔热灌注化疗联合全身化疗的疗效

Observation of postoperative early cyclic intraperitoneal hyperthermic perfusion combined with systemic chemotherapy on advanced gastric cancer patients

目的分析进展期胃癌术后早期循环式腹腔热灌注化疗联合全身化疗对生存情况及血清肿瘤标志物含量的影响。方法选择在该院接受手术治疗的进展期胃癌患者作为研究对象,随机分为接受术后单纯全身化疗的对照组、术后接受早期循环式腹腔热灌注化疗联合全身化疗的观察组患者,比较两组患者的血清肿瘤标志物、血管内皮生长因子(VEGF)、基质金属蛋白酶(MMP)水平以及远期生存情况。结果观察组患者接受治疗后的血清癌胚抗原(CEA)、糖链抗原19-9(CA19-9)水平均明显低于对照组患者(P<0.05)。观察组患者接受治疗后的血清VEGF、MMP-2与MMP-9水平均明显低于对照组患者(P<0.05)。观察组患者接受治疗后的2年复发率低于对照组,术后远期生存率高于对照组患者(P<0.05)。结论早期循环式腹腔热灌注化疗联合全身化疗有助于减少进展期胃癌术后患者的血清肿瘤标志物、VEGF及MMP水平,降低肿瘤恶性程度,延长远期生存时间。

[ Objective ] To analyze the efficacy of postoperative early cyclic intraperitoneal hyperthermic perfusion combined systemic chemotherapy on survival condition and serum tumor markers of advanced gastric cancer patients. [Methods] Advanced gastric cancer patients received surgery treatment in our hospital were chose for study and randomly divided into control group received postoperative systemic chemotherapy, observation group received postoperative early cyclic intraperitoneal hyperthermic perfusion combined with systemic chemotherapy. Then serum tumor markers, VEGF, MMPS levels and long-term survival situation were compared. [ Results ] Serum CEA, CA19-9 levels of observation group patients after treatment were significantly lower than control group （P 〈 0.05）. Serum VEGF, MMP-2 and MMP-9 levels of observation group patients after treatment were significantly lower than control group （P 〈 0.05）. 2 years recurrence rate of observation group patients was lower than control group; postop- erative long-term survival rate was higher than control group （P 〈 0.05）. [ Conclusion ] Early cyclic intraperitoneal hyperthermic perfusion combined with systemic chemotherapy is helpful to reduce serum tumor markers VEGF and MMPS levels of advanced gastric cancer patients, reduce tumor malignant degree, prolong the long-term survival time.