电子支气管镜下介入冷冻治疗联合全身化疗对晚期肺癌患者生存时间及血清学指标的影响被引量：9

Observation of advanced lung cancer patients with endobronchial tuberculosis treated by endoscopic interventional and systemic chemotherapy on survival time and serological indicator

下载PDF

导出

摘要目的分析电子支气管镜下介入冷冻治疗联合全身化疗对晚期肺癌患者生存时间以及血清学指标的影响。方法选择2011年7月-2012年7月在该院接受住院治疗的晚期肺癌患者86例作为研究对象,按照随机数表法将所有入组患者分为观察组(43例)接受电子支气管镜下介入冷冻治疗联合全身化疗,对照组(43例)接受单纯全身化疗,比较两组患者的血清肿瘤标记物水平、基质金属蛋白酶(MMP)含量、T细胞亚群水平及生存时间等差异。结果 1观察组患者接受治疗后血清CEA、NSE、CYFRA21-1及CA199等肿瘤标志物水平均明显低于对照组患者(P<0.05);2观察组患者接受治疗后血清MMP-2、MMP-9及CD8+水平低于对照组,CD4+和CD4+/CD8+水平高于对照组(P<0.05);3观察组患者接受治疗后1年生存率高于对照组,平均生存期及中位生存时间明显长于对照组(P<0.05)。结论电子支气管镜下介入冷冻治疗联合全身化疗可以有效降低晚期肺癌患者血清肿瘤指标及血管生成因子水平,提升全身免疫功能及生存时间。 [ Objective ] To observe the influence factors of advanced lung cancer patients with endobronchial tu- berculosis treated by endoscopic interventional and systemic chemotherapy on survival time and serological indicator. [Methods] 86 cases of advanced lung cancer patients from July 2011 to July 2012 in our hospital, according to stochastic indicator method divided into observation group （43 cases） received endobronchial tuberculosis treated by endoscopic interventional and systemic chemotherapy, control group （43 cases） received pure systemic chemotherapy, compared serum tumor markers, MMP, content and level of T cell subgroup, survival time. [ Results ] Observation group patients＂ serum CEA, CA199, NSE, CYFRA21-1 levels were significantly lower than control group patients （P 〈 0.05）; Observation group patients＂ serum levels of MMP-2, MMP-9, CD8^＋ levels were lower than control group, CD4^＋, CD4^＋/CD8^＋ levels were higher than control group （P 〈 0.05）; Observation group patients＂ 1 year survival rate was higher than control group after treatment, average survival period and the median survival time were significantly longer than control group （P 〈 0.05）. [ Conclusion ] Endoscopic interventional treatment combined with systemic chemotherapy can effectively reduce advanced lung cancer patients＂ angiogenesis factor levels and serum tumor marker, improve body immune function and survival time.

作者张海容

机构地区浙江省宁波市北仑区人民医院呼吸内科

出处《中国现代医学杂志》 CAS 北大核心 2015年第31期62-65,共4页 China Journal of Modern Medicine

关键词晚期肺癌电子支气管镜介入冷冻治疗生存时间 advanced lung cancer electronic bronchoscope interventional cryotherapy survival time

分类号 R734.2 [医药卫生—肿瘤]

引文网络
相关文献

参考文献13

1DU RAND IA, BARBER PV, GOLDRING J, et al. Summary of the british thoracic society guidelines for advanced diagnostic and therapeutic flexible bronchoscopy in adults[J]. Thorax, 2011, 66 (11): 1014-1015.
2GOMPELMANN D, EBERHARDT R, HERTH FJ. Advanced malignant lung disease: what the specialist can offer[J]. Respira- tion, 2011, 82(2): 111-123.
3OKI M, SAKA H, ANDO M, et al. Endoscopic ultrasound-guid- ed fine needle aspiration and endobronchial ultrasound-guided transbronchial needle aspiration: Are two better than one in me- diastinal staging of non-small celllung cancer[J]. J Thorac Car- diovasc Surg, 2014, 148(4): 1169-1177.
4KANEKO M. Changes and current state of diagnosis of lung cancer after development of the flexible bronchofiberscope[J]. Jpn J Clin Oncol, 2010, 40(9): 838-845.
5NASIR BS, BRYANT AS, MINNICH DJ, et al. The efficacy of restaging endobronchial ultrasound in patients with non-small cell lung cancer after preoperative therapy[J]. Ann Thorac Surg, 2014, 98(3): 1008-1012.
6陈乐蓉,陈中书,邹禄如,殷塔耀.经支气管镜介入冷冻加注药治疗支气管结核疗效观察[J].中国内镜杂志,2013,19(9):986-989. 被引量：20
7AGAIMY A, KOCH M, LELL M, et al. SMARCBI(INI1)-defi- cient sinonasal basaloid carcinoma: a novel member of the ex- panding family of SMARCBl-deficient neoplasms[J]. Am J Surg Pathol, 2014, 38(9): 1274-1281.
8NENSA F, STATTAUS J, MORGAN B, et al. Dynamic con- trast-enhanced MRI parameters as biomarkers for the effect of vatalanib in patients with non-small-cell lung cancer[J]. Future Oncol, 2014, 10(5): 823-833.
9WIELPUTZ MO, HEUBEL CP, HERTH FJ, et al. Radiological diagnosis in lung disease: factoring treatment options into the choice of diagnostic modality[J]. Dtsch Arztebl Int, 2014, 111 (11): 181-187.
10冯华松,孟激光,聂舟山,韩志海,张新红,丁新民,李泳群,李毅,张燕,刘永勤.经支气管镜冷冻治疗中央型肺癌所致的气道腔内梗阻[J].海军总医院学报,2010,23(2):70-72. 被引量：5

二级参考文献18

1杨红忠,胡成平,杨华平,陈琼,瞿素洁.支气管镜介入冷冻治疗支气管结核[J].中国防痨杂志,2005,27(4):227-229. 被引量：45
2Bertoletti L,Elleuch R,Kaczmarek D,et al.Bronchoscopic cryotherapy treatment of isolated endoluminal typical carcinoid tumor[J].Chest,2006,130(5):1405-1411.
3Vergnon JM,Huber RM,Moghissi K.Place of cryotherapy,brachytherapy and photodynamic therapy in therapeutic bronchoscopy of lung cancers[J].Eur Respir J,2006,28(1):200-218.
4De Gracia J,Culebras M,Alvarez A,et al.Bronchoscopic balloon dilatation in the management of bronchial stenosis following lung transplantation[J].Respir Med,2007,101(1):27-33.
5Bolliger CT,Sutedja TG,Strausz J,et al.Therapeutic bronchoscopy with immediate effect:laser,electrocautery,argon plasma coagulation and stents[J].Eur Respir J,2006,27(6):1258-1271.
6Sohrab S,Mathur PN.Management of central airway obstruction[J].Clin Lung Cancer,2007,8(5):305-312.
7Herth FJ,Eberhardt R,Ernst A.The future of bronchoscopy in diagnosing,staging and treatment of lung cancer[J].Respiration,2006,73(4):399-409.
8Amorico MG,Drago A,Vetruccio E,et al.Tracheobronchial stenosis:role of virtual endoscopy in diagnosis and follow-up after therapy[J].Radiol Med,2006,111(8):1064-1077.
9Forest V,Peoc'h M,Campos L,et al.Benefit of a combined treatment of cryotherapy and chemotherapy on tumour growth and late cryo-induced angiogenesis in a non-small-cell lung cancer model[J].Lung Cancer,2006,54(1):79-86.
10Marinho FC ,Takagaki TY. Hypercoagulability and lung cancer[ J ]. J Bras Pneumol, 2008,34 (5) :312 - 322.