摘要
阳离子类脂是近年来一类发展较快的非病毒类载体。阳离子类脂主要由疏水尾部、连接键和带氨基的亲水头部组成。疏水尾部、连接键和带氨基亲水头部的不同对阳离子类脂基因转染效率具有很大的影响。文中通过检索大量国内外新型阳离子类脂的相关文献,从阳离子类脂的结构组成和助类脂等对基因转染效率的影响因素进行综述,并展望了新型阳离子类脂的前景。
The cationic lipid is a rapidly developing non-viral vector in recent years. Cationic lipid is mainly composed of hydrophobic tails, join keys and hydrophilic head with ammonia. The difference in hydrophobic tail, join keys and the hydrophilic head with ammonia has a great influence on the efficiency of cationic lipid gene transfection. By retrieving domestic and oversea literature related to new type cationic liposome, we reviewed the factors impacting efficiency of lipid gene transfection, such as structural composition of cationic lipid, helper lipids and so on. The prospect of new type cationic liposomes was also proposed.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2015年第22期2589-2593,共5页
Chinese Journal of New Drugs
基金
广东省科技厅公益研究和能力建设专项资金(2015A020211035)
关键词
亲水头部
连接键
疏水尾部
助类脂
hydrophilic head
join key
hydrophobic tail
helper lipid
