健康体检人群尿酸水平对血细胞参数的影响

Uric acid level on hematological parameters in health examination population

目的探讨健康体检人群尿酸水平对红细胞(red blood cell,RBC)、白细胞(white blood cell,WBC)及血小板(platelets,PLT)各参数的影响。方法选择健康体检人群1 037例作为研究对象,按性别及尿酸(uric acid,UA)水平分为4组,其中A组为男性高尿酸血症202例,B组为男性UA正常320例,C组为女性高尿酸血症170例,D组为女性UA正常345例。检测每个研究对象UA、RBC、血红蛋白(hemoglobin,HB)、红细胞比容(hematocrit,HCT)、红细胞体积分布宽度(red cell distribution width,RDW)、PLT、血小板压积(plateletcrit,PCT)、血小板分布宽度(platelet distribution width,PDW)、WBC。结果高尿酸血症组在UA、RBC、RDW、PLT、PCT、HCT、HB水平明显高于UA正常组(P<0.01)。UA水平与HCT、HB、RBC、RDW、WBC有一定正相关(r=0.298、0291、0.27、0.19和0.081,P<0.01),与PLT相关参数无相关性。结论随着UA浓度升高,血细胞各项参数有不同程度的升高。

Objective To explore the influence of uric acid（UA）on the parameters of red blood cell（RBC）,white blood cell（WBC）and platelet（PLT）in health examination population.Methods Totally 1 037 individuals from health examination were divided into four groups by gender and the levels of UA,male hyperuricemia,male normal UA,female hyperuricemia and female normal UA.The levels of UA,RBC,hemoglobin（HB）,hematocrit（HT）,RBC distribution width（RDW）,PLT,PCT,PLT distribution width（PDW）and WBC were detected in all participants.Results UA,RBC,RDW,PLT,PCT,HCT and HB in hyperuricemia group were significantly higher than those in normal UA group.UA level had obvious positive correlation with HCT,HB,RBC,RDW and WBC（r=0.298,0291,0.27,0.19 and 0.081,all P〈0.01）.UA had no correlation with PLT related indexes.Conclusion Hematological parameters have varying degrees of increase by UA.