新型抗癫痫药托吡酯治疗癫痫的临床研究

Clinical Observation of a Newly-developed Antiepileptic——Topiramate in Treatment of Epilepsy

目的 :观察托吡酯治疗癫痫的临床疗效及安全性。方法 :采用开放性试验 ,对15例难治性癫痫患者进行托吡酯添加治疗以及对61例新诊断的癫痫患者进行托吡酯单药治疗。结果 :15例难治性癫痫发作频率减少≥50 %者10例 ,有效率66 7 % ,其中2例发作停止 ;61例新诊断的癫痫发作频率减少≥50 %者45例 ,有效率73 8 % ,其中16例 (26 2 % )完全控制。不良反应发生率低 ,且程度较轻。结论 :托吡酯不论作为添加治疗或单药治疗 ,对多种癫痫发作形式均有良好的疗效 。

OBJECTIVE:To observe the efficacy and safety of topiramate in treatment of epilepsy METHODS:15 patients with refractory epilepsy treated with topiramate as additive drug and 61 newly-diagnosed epileptic patients with topiramate as monotherapeutic agent entered the open-label trial and were followed-up RESULTS:Among 15 patients with refractory epilepsy, the frequency of seizure decreased by 50% or greater in 10 cases with an effective rate of 66 7%, and 2 patients were free from seizure;among 61 newly-diagnosed cases, the frequency of seizure reduced by 50% or more in 45 cases(73 8%), and 16 cases were free from seizure(26 2%) The ARDs were lower in incidence and mild in severity CONCLUSION:Topiramate was safe and effective as additive or monotherapeutic agent for multiple types of seizure