基于血清胱抑素C水平分析冠心病患者肾功能与心功能的关系

Analysis of renal function and cardiac function in patients with coronary artery disease based on serum cystatin Clevel

目的探讨冠心病患者血清胱抑素C水平与心肾功能的关系。方法选取2011年8月至2014年10月来我院就诊确诊的冠心病患者98例,依据造影结果分为单支血管病变组(49例)和多支血管病变组(49例),采用免疫比浊法检测胱抑素C(Cys-C)、β2微球蛋白(β2MG)水平,超声心动仪测定左心室舒张末期直径(LVEDD),采用辛普森法测得左心室射血分数(LVEF),比较分析2组患者指标水平,并进行相关性分析。结果多支血管病变组患者Cys-C、LVEF、LVEDD、β2MG、尿素氮(BUN)、血肌酐(Scr)的水平均显著高于单支血管病变组(P<0.05);Cys-C与LVEF水平呈负相关(r=-0.746,P<0.05),Cys-C与LVEDD水平呈正相关(r=0.638,P<0.05),Cys-C与β2MG、BUN、Scr水平均呈正相关(r=0.384、0.729、0.455,P<0.05);LVEF与β2MG、BUN、Scr水平均呈负相关(r=-0.283、-0.705、-0.692,P<0.05),LVEDD与β2MG、BUN、Scr水平无显著相关性(r=0.015、0.012、0.018,P>0.05)。结论冠心病患者血清胱抑素C水平与心、肾功能有关,可反映早期肾损伤及心室重构。

Objective To investigate the correlation between serum cystatin C level and heart and kidney func-tion in patients with coronary heart disease（CHD）.Methods A total of 98 patients diagnosed with CHD in our hospital between August 2011 and October 2014 were included in the study,and divided into the single-vessel disease group（n=49） and multi-vessel disease group（n=49） based on angiography.Immunoturbidimetry was used to determine cystatin C（Cys-C） and β2-microglobulin（β2MG） level.The left ventricular end-diastolic diameter（LVEDD） was determined by echocardiography,and the left ventricular ejection fraction（LVEF） was determined by Simpson method.The index levels in the two groups were compared,and the correlation was analyzed.Results The Cys-C,LVEF,LVEDD,β2MG,BUN and Scr levels in patients with multi-vessel disease were significantly higher than those in patients with single-vessel disease（P〈0.05）.Cys-C and LVEF levels was negatively correlated（r=-0.746,P〈0.05）.Cys-C and LVEDD levels was positively correlated（r=0.638,P〈0.05）.Cys-C was positively correlated with β2MG,BUN and Scr levels（r=0.384,0.729,0.455,P〈0.05）.LVEF was negatively correlated with β2MG,BUN and Scr levels（r=-0.283,-0.705,-0.692,P〈0.05）.LVEDD and β2MG,BUN,Scr levels were not significantly correlated（r =0.015,0.012,0.018,P〈0.05）.Conclusion Serum Cys-C levels may correlated with heart and kidney function in CHD patients,which reflects early renal damage and ventricular remodeling.