2型糖尿病患者颈动脉粥样硬化与血清网膜素-1的相关研究

Correlation between serum omentin-1 and carotid atherosclerosis in patients with type 2 diabetes

目的探讨血清网膜素-1与2型糖尿病(T2DM)患者颈动脉粥样硬化(CAS)的关系。方法选取30例新诊断T2DM不伴CAS患者及30例T2DM伴CAS患者作为研究组,30名正常糖耐量(NGT)者作为对照组。酶联免疫吸附试验(ELISA)法测定血清网膜素-1水平,并测定空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、空腹胰岛素(FINS)、血脂等指标;CAS检测采用彩色多普勒超声仪。结果 1血清网膜素-1水平在T2DM伴CAS组、新诊断T2DM不伴CAS组均明显低于NGT组[(45±12)和(73±12)和(86±27)ng/L(P<0.05或P<0.01)];在CAS组较非CAS组显著降低(P<0.01)。2血清网膜素-1与体质量指数(BMI)、FPG、Hb A1c、FINS、胰岛素抵抗指数(HOMA-IR)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)呈负相关(P<0.05或P<0.01),与高密度脂蛋白胆固醇(HDL-C)呈正相关(P<0.01)。3网膜素-1是CAS的独立保护因素,HOMA-IR是CAS的独立危险因素。结论血清网膜素-1水平随着糖尿病病情发展逐渐降低,可能参与了T2DM患者CAS的发生。

Objective To investigate the correlation between serum omentin-1 and carotid atherosclerosis（CAS） in patients with type 2 diabetes（T2DM）.Methods Thirty cases of newly diagnosed T2 DM without CAS and30 of T2 DM with CAS were included in the experimental group.Thirty cases with normal glucose tolerance（NGT）were included in the control group.Enzyme-linked immuno sorbent assay（ELISA） was used to determine serum omentin-1 level.Also,the fasting blood glucose,glycated hemoglobin,fasting insulin,and blood lipids were deter-mined.CAS was determined by color Doppler ultrasound.Results ①The serum omentin-1 level in T2 DM with CAS group and newly diagnosed T2 DM without CAS group was significantly lower than that in NGT group [（45 ±12） vs（73±12） vs（86 ±27） ng/L（P〈0.05 or P〈0.01）].However,the serum omentin-1 level was significantly decreased in CAS group compared with that in non-CAS group（P〈0.01）.②The serum omentin-1 level was negatively correlated with BMI,FPG,Hb A1 c,FINS,HOMA-IR,TG and LDL-C（P〈0.05 or P〈0.01）,and positively correlated with HDL-C（P〈0.01）.③Omentin-1 was the independent protective factor of CAS,and HOMA-IR was the independent risk factor of CAS.Conclusion Serum omentin-1 level gradually decreases with the progression of diabetes,which may be in-volved in the occurrence of CAS in T2 DM patients.