人羊膜干细胞:再生医学的理想种子细胞资源

Human amniotic stem cells:Ideal seed cells source for regenerative medicine

人羊膜干细胞具有高度自我更新、增殖、可植入性和多系分化能力,异基因个体移植后无免疫排斥和致瘤性风险。而且,人羊膜干细胞来源于产妇分娩后废弃的胎盘,应用到临床不会带来医学伦理争议。本文从人羊膜干细胞生物学特性及多系分化潜能两方面,综述了其作为细胞治疗及组织工程的种子细胞应用的巨大潜力。无论人羊膜间充质干细胞还是人羊膜上皮细胞均可用来进行诸多疾病的细胞治疗、组织器官损伤的修复与重建,是再生医学领域理想的种子细胞资源,具有广阔的临床应用前景。

Human amniotic stem cells have a higher self - renewal ability and extensive characteristics of proliferation in vitro, their imbedding and multi - differential potentialities. Human amniotic stem ceils have no any risks due to some good properties such as low immunogenicity, and non-tumorigenicity. Furthermore, they are isolated from the waste placenta after delivery, and are unable to result in a medical ethics controversy. In this present study, the latest development of the cell therapy with the human amniotic stem cells and the application of the seed cells in the regenerative medicine were outlined on the basis of the research progress about biological properties and multi -differential potentialities at home and abroad. Both human amniotic mesenchymal stem cells and human amniotic epithelial cells could be used as seed cells for the cell therapy against different diseases, and the reparation and reconstruction of the impaired human tissues and organs. Therefore, they are an ideal seed cell source for the regenerative medicine, and have a promising prospect in clinical application.