HIF-1α、VEGF在稽留流产绒毛中的表达及意义

EXPRESSION AND SIGNIFICANCE OF HIF-1α,VEGF IN VILLI OF PATIENTS WITH MISSED ABORTION

目的检测稽留流产绒毛中缺氧诱导因子-1α(HIF-1α)及血管内皮生长因子(VEGF)的表达及二者之间的相关性。方法免疫组化SP法检测厚街医院稽留流产60例及正常早孕20例患者绒毛中HIF-1α、VEGF的表达。结果 HIF-1α及VEGF在稽留流产患者绒毛中的表达均明显低于正常早孕妇女绒毛中的表达,两组间表达水平有显著性差异(p<0.05),HIF-1α与VEGF呈显著正相关(r=0.706,p<0.05)。结论 HIF-1α、VEGF表达降低可能是导致稽留流产发生的重要因素。

Objective To detect the expression and correlation of hypoxia - inducing factor - 1 alpha （ HIF - 1 α） and vascular endothelial growth factor （VEGF） in villi of patients with missed abortion. Methods Immunohis- tochemical SP analysis were performed to detect the expression of HIF - 1 α and VEGF in 60 patients of missed abortion and 20 patients of normal pregnancy in Houjie hospital. Results The expression of HIF - 1 alpha and VEGF in villi of patients with missed abortion were significantly lower than the expression in normal pregnancy villi, and the expression levels between the two groups have significant difference （p 〈 0.05 ）. A significant positive correlation occured between HIF - 1 α and VEGF （ r = 0. 706 ,p 〈 0.05 ）. Conclusion The expression of HIF - 1 α and VEGF re- duction may be the important factors that result in missed abortion.