镇惊定志合剂治疗中风后抑郁临床研究

Clinical Observation on Post-Stroke Depression Treated By Zhenjing Dingzhi Mixture

目的观察镇惊定志合剂治疗中风后抑郁的临床疗效。方法采用随机单盲方法,以中风后抑郁患者为研究对象,将80例患者随机分为治疗组与对照组,每组40例,治疗组在原有治疗的基础上加用镇惊定志合剂,对照组在原有治疗的基础上给予氟西汀治疗,两组疗程均为12周。观察两组治疗前后抑郁自评量表(Zung)、汉密尔顿抑郁量表(HAMD)、日常活动能力量表(ADL)的评分变化情况,并采用不良反应量表(TESS)观察不良反应发生情况。结果 Zung量表评分治疗12周后,治疗组总有效率为80.0%,对照组总有效率为70.3%;HAMD量表评分:治疗12周后,治疗组总有效率为70.0%,对照组总有效率为75.7%,两组疗效相当(P>0.05);在改善患者日常活动能力方面治疗组明显优于对照组(P<0.05);治疗组的TESS评分显著低于对照组(P<0.01)。结论镇惊定志合剂可有效改善PSD患者抑郁症状,且不良反应少。

Objective To observe the clinical effects of Zhenjing Dingzhi mixture（ ZDM） in treatment of post-stroke depression（ PSD）. Methods Eighty patients with PSD were randomly divided into two groups： The control group（n = 40） treated with routine treatment plus fluoxetine,and the treatment group（n = 40） treated with routine treatment plus ZDM for 12 weeks. The degree of depression was evaluated by Zung Selfrating Depression Scale（ SDS）,Hamiltion Depression Rating Scale（ HAMD）,activities of daily living（ ADL）. The adverse reaction was observed by Treatment Emergent Symptom Scale（ TESS）. Results The scores of Zung rating scale shows that total effective rate was 80% in treatment group,70. 3% in control group after 12 weeks treatment. The scores of HAMD rating scale showed that total effective rate was 70%in treatment group,75. 7% in control group after 12 weeks treatment. There was no significant difference between two groups（P〈0. 05）.The scores of ADL rating scale showed that curative effect in treatment group was better than that in control group（P〈0. 05）. The adverse reactions in treatment group was lower than that in control group（P〈0. 01）. Conclusion ZDM can alleviate the symptoms of depression in patients with PSD,with fewer adverse reactions as well.