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程序性细胞死亡因子4在视网膜母细胞瘤组织中的表达及与临床病理的关系研究

Expression of programmed cell death 4 and its relationship with clinical stage and histodifferentiation in retinoblastoma
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摘要 目的探讨视网膜母细胞瘤(RB)组织中程序性细胞死亡因子4(PDCD4)的表达及其与临床分期和组织分化的关系。方法应用免疫组织化学S-P法检测PDCD4在35例RB组织中的表达;用MPIAS-500彩色病理图像分析系统测量其平均积分光密度值。结果在35例RB组织切片中,均可见PDCD4的阳性表达,其表达水平明显低于正常视网膜组织(P<0.05);眼外扩展期组PDCD4的表达水平明显低于眼内生长期组和眼压增高期组(P<0.05);PDCD4在RB的阳性表达水平与肿瘤组织的分化程度及视神经浸润显著相关(P<0.05)。结论 PDCD4蛋白表达水平与RB的临床分期、视神经浸润以及组织分化有关,PDCD4可作为判断RB浸润及预后的指标。 Objective To investigate the expression of programmed cell death 4 （PDCIM） in retinoblastoma （RB） and its relationship with clinical stage and histodifferentiation. Methods Immunohistochemical technique was used to detect the expression of PDCIM in RB samples of 35 cases. The quantitative analysis of the PDCD4 expression was assessed by using MPIAS-500 color pathologic analysis system. Results PDCIM was expressed positively in the all 35 Rb specimens. The level of PDCIM expression was significantly lower in RB than that in normal retina tissues （ P 〈 O. 05）. The expression of PDCIM was related to the histodifferentiation and optic nerve infiltration （ P 〈 0. 05 ）. Conclusions The expressions of PDCIM was associated with clinical stage and histodifferentiation in RB. PDCIM may become a new marker for the invasion and prognosis of RB.
作者 武犁 周芸芸 陈樱
机构地区 武汉大学人民医院眼科
出处 《中国眼耳鼻喉科杂志》 2015年第6期403-405,共3页 Chinese Journal of Ophthalmology and Otorhinolaryngology
关键词 视网膜母细胞瘤 程序性细胞死亡因子4 免疫组织化学 组织分化 Retinoblastoma Programed cell death 4 Immunohistochemistry Histodifferentiation
分类号 R739.7 [医药卫生—肿瘤]
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参考文献15

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共引文献13

中国眼耳鼻喉科杂志
2015年 第6期

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