六味地黄丸对儿童原发性肾病综合征外周血清IgE和CD23的影响及其疗效观察

Effect of Liuwei Dihuang Pills on peripheral blood IgE and CD23 in children with primary nephrotic syndrome and efficacy observation

目的观察经六味地黄丸治疗后的儿童肾病综合征患者外周血清IgE和CD23的浓度变化及其近期临床疗效。方法选取儿童肾病综合征患者60例,分为对照组和观察组,每组30例,对照组给予常规治疗,观察组在常规治疗的基础上给予六味地黄丸,连续治疗6周,观察两组的近期临床疗效及患者外周血清中IgE和CD23的浓度变化。结果治疗后观察组近期临床疗效均优于对照组(P<0.05);治疗后两组患者外周血清中总胆固醇(TC)、总三酰甘油(TG)、血清肌酸酐(SCr)、血清尿素氮(BUN)及其IgE、CD23的浓度均较治疗前降低(P<0.05);治疗后观察组患者外周血清中TC、TG、SCr、BUN及其IgE、CD23的浓度均低于对照组(P<0.05)。结论在常规治疗的基础上给予六味地黄丸能很好地改善小儿肾病综合征患者的近期临床疗效。在治疗过程中全面、细致、规范化的护理是治疗成功的基础。

Objective To observe the changes of peripheral serum IgE and CD23 levels and short clinical efficacy after the treatment of Liuwei Dihuang Pills in children patients with primary nephrotic syndrome.Methods 60 children patients with primary nephrotic syndrome were selected and randomly divided into the control group and the observation group,30 cases in each group.The control group was given the conventional treatment,while on this basis the observation group was given Liuwei Dihuang Pills.The treatment lasted for 6weeks.The short term clinical efficacy and the changes of peripheral serum IgE and CD23 levels were observed.Results The short term clinical efficacy after treatment in the observation group was significantly better than that in the control group（P〈0.05）;the levels of peripheral serum TC,TG,SCr,BUN and IgE,CD23 after treatment in the two groups were decreased compared with those before treatment（P〈0.05）;the levels of peripheral serum TC,TG,SCr,BUN and IgE,CD23 after treatment in the observation group were lower than those in the control group（P〈0.05）.Conclusion Giving Liuwei Dihuang Pills on the basis of basic treatment can better improve the short term clinical effect.The comprehensive,careful and normative nursing care during the treatment process is the foundation of the treatment success.