血清P-选择素及E-选择素对急诊危重患儿病情及生存状况的评估价值分析

Analysis on evaluation value of serum P-selectin and E-selectin on disease conditions and survival status in children with critical illness

目的探究血清P-选择素及E-选择素水平对急症危重患儿病情及生存状况的影响。方法选取2013年1月至2014年10月接受治疗的50例重症危重患儿(试验组)和50例同期体检的健康儿童(健康对照组)。比较两组研究对象血清P-选择素及E-选择素的变化情况。结果试验组患儿治疗前的P-选择素和E-选择素水平均高于健康对照组,差异有统计学意义(P<0.05);治疗后两组间差异均无统计学意义(P>0.05)。不同PCIS评分的P-选择素、E-选择素水平均不同,PCIS评分越低,患儿的P-选择素、E-选择素水平越高,差异有统计学意义(P<0.05)。不同程度脓毒症患儿的P-选择素、E-选择素水平均不同,非感染危重症患儿的P-选择素、E-选择素水平较低,脓毒症患儿其次,严重脓毒症患儿最高,差异均有统计学意义(P<0.05)。结论血清P-选择素及E-选择素对急症危重患儿病情及生存状况具有重要影响。急症危重患儿的病情越严重,生存状况越差,患者的血清P-选择素及E-选择素水平越高,对患儿进行手术抢救的成功率越低,患儿病死率越高。

Objective To explore the influence of serum P-selectin and E-selectin on the disease condition and survival status in children patients with acute sritical illness.Methods 50 children cases of critical ill（experimental group）and contemporaneous 50 healthy children undergoing the physical examination（healthy control group）treated in our hospital from January 2013 to October 2014 were selected.The changes of serum P-selecting and E-selectin levels were compared between the two groups.Results The P-selectin and E-selectin levels before treatment in the experimental group were higher than those in the control group,the difference was statistically significant（P〈0.05）;the difference in P-selectin and E-selectin levels after treatment had no statistical difference between the two groups（P〈0.05）,the E-selectin and E-selectin levels were different among different PCIS scores,the lower the PCIS score was,the higher the P-selectin and E-selectin were,the differences were statistically significant（P〈0.05）.The P-selectin and E-selectin levels were different among different degrees of sepsis.The P-selectin and E-selectin levels in the critical ill children patients with non-infection disease were lower,followed by sepsis and which in severe sepsis were highest,the differences were statistically significant（P〈0.05）.Conclusion Serum P-selectin and E-selectin have important influence on the disease condition and survival status in critical ill children patients.The disease condition is more serious,the survival status is worse,the P-selectin and E-selectin levels are higher,the success rate of operative rescue is lower and the children patients fatality rate is higher.