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长链非编码核糖核酸ANRIL与糖脂代谢性疾病 被引量：1

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摘要 近年来随着全基因组关联研究 （ Genome Wide As-so-ciation Study, GWAS） 的深入, 人们对染色体9p21基因区段的认识大为增加[1-3]. 尽管该区段最早在2007年被发现与冠状动脉性心脏病 （ coronary heart disease, CHD） 发病密切相关[1, 3] , 但此后的研究发现9 p21区段不仅与2型糖尿病、 心肌梗死密切相关,也与腹主动脉瘤、 外周血管病、 卵巢癌、 子宫内膜异位、 颅内动脉瘤等多种疾病具有显著相关性[4]. 值得注意的是, 染色体9 p21区段中与CHD、 2型糖尿病相关的单核苷酸多态性 （ single nucleotide polymorphism, SNP） 位点几乎都位于不编码蛋白质的 ＂基因沙漠＂中[3].
作者 梁微微 李乃适
机构地区 中国医学科学院北京协和医学院北京协和医院内分泌科卫生部内分泌重点实验室
出处 《协和医学杂志》 2015年第6期458-461,共4页 Medical Journal of Peking Union Medical College Hospital
基金 2014年度留学人员科技活动项目择优资助项目(重点类)
关键词 ANRIL 糖脂代谢
分类号 Q756 [生物学—分子生物学]
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协和医学杂志
2015年 第6期

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