肺癌恶性胸腔积液中医证型分布的相关性研究

Study on the correlation of distribution characteristics of TCM syndrome types of malignant pleural effusions of Patients with Lung cancer

目的研究肺癌恶性胸腔积液中医证型与病理类型、性别、年龄、积液量的关系。方法选择石家庄市中医院住院的125例明确诊断的肺癌恶性胸腔积液患者作为研究对象,收集患者的病理类型、性别、年龄、积液量、影像资料及中医四诊等临床资料;参照文献及科室经验,将其辨证分为4型。利用SPSS统计软件分析肺癌恶性胸腔积液中医分型与病理类型、性别、年龄、积液量之间的关系。结果 (1)肺癌恶性胸腔积液的不同病理类型的中医证型分布经卡方检验无显著性差异(P>0.05);(2)不同性别的肺癌恶性胸腔积液患者,中医证型分布经卡方检验无显著性差异(P>0.05);(3)不同年龄段的肺癌恶性胸腔积液患者的中医证型分布经卡方检验有显著性差异(P<0.05);(4)在积液量方面,中医证型分布情况经卡方检验无差异性(P>0.05);(5)肺癌恶性胸腔积液的4个证型中最常见的是脾肾阳虚证、气阴两虚证。结论肺癌恶性胸腔积液中医证型与病理类型、性别、积液量无明显相关性;与年龄段具有一定的相关性。这可能为中医诊治肺癌恶性胸腔积液提供一定的参考依据,为肺癌恶性胸腔积液的中医规范化治疗打下一定基础。

Objective To study the correlation between TCM syndrome types distribution characteristics of Malignant Pleural Effusion（ MPE） and pathological type,gender,age,and effusion quantity.Methods 125 patients of MPE caused by lung cancer that diagnosed definitely were chosen as research object,to collect pathological type,gender,age,effusion quantity,image data and information of 4 diagnostic methods with TCM; in the meantime,on the basis of literature and the experience of the department,all the patients were divided into 4 TCM syndrome types. To analyze relationship between TCM syndrome types and pathological type,gender,age,effusion quantity by means of SPSS. Results There were no significant differences between pathological type and TCM syndrome types via Chi-square test; the distribution of TCM syndrome types in patients with different gender was no significant difference; the difference was significant in the distribution of TCM syndrome types in patients with different age group; there was no significant difference between the TCM syndrome types and effusion quantity; spleen-kidney yang deficiency and deficiency of qi and yin were the most common TCM syndrome types of MPE caused by lung cancer.Conclusions There was no obvious correlation between TCM syndrome types of MPE caused by lung cancer and pathological type,gender,effusion quantity; TCM syndrome types were closely correlated with age. Thiscould provide some references for diagnosis and treatment of MPE caused by lung cancer by using TCM,and lay a foundation for the standardization of TCM treatment of MPE caused by lung cancer.