急性脑梗死患者外周血清巨噬细胞移动抑制因子、基质金属蛋白酶-9和超敏C-反应蛋白水平与病情严重程度的关系

Relationship of Serum Macrophage Migration Inhibitory Factor, Matrix Metalloproteinase-9 and Hypersensitive C-Reactive Protein with Severity of Acute Cerebral Infarction

目的：探讨急性脑梗死患者血清巨噬细胞移动抑制因子（MIF）、基质金属蛋白酶-9（MMP-9）、超敏C-反应蛋白（hs-CRP）水平与病情严重程度的相关性。方法急性脑梗死患者101例根据美国国立卫生研究院卒中量表（NIHSS）评分分为轻型脑梗死组（A组，NIHSS评分〈4分，n=38）、中型脑梗死组（B组，NIHSS评分4~15分，n=36）和重型脑梗死组（C组，NIHSS评分〉15分，n=27）；同期住院44例有动脉粥样硬化危险因素非急性脑梗死患者为对照组（D组）。酶联免疫吸附法测定血清中MIF、MMP-9水平，免疫散射比浊法检测hs-CRP水平。结果各组间MIF、MMP-9及hs-CRP水平从高到低依次为C组、B组、A组、D组（P〈0.05）。MIF与MMP-9（r=0.301, P〈0.01）和hs-CRP （r=0.309, P〈0.001）呈正相关。结论急性脑梗死患者血清MIF、MMP-9、hs-CRP水平升高，可能预测动脉粥样硬化斑块稳定性。

Objective To investigate the relationship of serum levels of macrophage migration inhibitory factor （MIF）, matrix metallo-proteinase-9 （MMP-9）, hypersensitive C-reactive protein （hs-CRP） with the severity of acute cerebral infarction （ACI）. Methods 101 pa-tients with ACI were envolved and divided into 3 groups according to the scores of National Institute of Health Stroke Scale （NIHSS）：mild group （group A, n=38, NIHSS score〈4）, moderate group （group B, n=36, NIHSS score 4-15） and severe group （group C, n=27, NIHSS score＆gt;15）. Meanwhile, 44 non-ACI inpatients with atherosclerosis were included as control group （group D）. Their serum MIF and MMP-9 were detected with ELISA, and hs-CRP with immunoturbidimety. Results The levels of serum MIF, MMP-9 and hs-CRP ranged from more to less as groups C, B, A and D （P〈0.05）. There was positive correlation of MIF with MMP-9 （r=0.301, P〈0.01） and hs-CRP （r=0.309, P〈0.001）. Conclusion Serum MIF, MMP-9 and hs-CRP levels increased with the severity in ACI patients, which may be prediction of athero-sclerotic plaque instability.