诱导型一氧化氮合酶的研究进展

Research progress of inducible nitric oxide synthase regulation

诱导型一氧化氮合酶（iNOS）产生一氧化氮（NO）在炎症、感染、癌症等多种疾病中发挥着重要的作用。iNOS基因多态性与多种疾病有关，而iNOS也受多种因素调节。作为体内氧化应激精细调节的一部分，认识iNOS的调控机制，对于探索感染、肿瘤和免疫等过程非常必要。近年来，有关机体对iNOS的调控作用的研究主要集中在转录水平、转录后翻译水平、抑制剂分子等方面并取得了较大进展。

Inducible nitric oxide synthase （iNOS） generates nitric oxide＇（ NO）, and it also plays an important roles in inflammation,infection and cancer. Gene polymorphism of iNOS is related to some diseases, while iNOS is regulated by some factors. As a part of fine regulation in oxidation stress ,the mechanism of iNOS regulation is essential to elucidatete process such as infection, tumor and immunity. Here we summarize the re- search progress about iNOS in the area of its transcription, post-transcription, and molecular inhibitors.